BRAF-inhibitor Associated MEK Mutations Increase RAF-Dependent and -Independent Enzymatic Activity
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DOI: 10.1158/1541-7786.mcr-17-0211
Abstract: Alterations in MEK1/2 occur in cancers, both in the treatment-naïve state and following targeted therapies, most notably BRAF and MEK inhibitors in BRAF-V600E–mutant melanoma and colorectal cancer. Efforts were undertaken to understand the effects of… read more here.
Keywords: inhibition; braf inhibitor; activity; mek1 alterations ... See more keywords