The meiotic-specific Mek1 kinase in budding yeast regulates interhomolog recombination and coordinates meiotic progression with double-strand break repair
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DOI: 10.1007/s00294-019-00937-3
Abstract: Recombination, along with sister chromatid cohesion, is used during meiosis to physically connect homologous chromosomes so that they can be segregated properly at the first meiotic division. Recombination is initiated by the introduction of programmed… read more here.
Keywords: kinase; double strand; recombination; activity ... See more keywords
Allosteric Kinase Inhibitors Reshape MEK1 Kinase Activity Conformations in Cells and In Silico
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DOI: 10.3390/biom11040518
Abstract: Mutations at different stages of the mitogen-activated protein kinase (MAPK) signaling pathway lead to aberrant activation of the involved protein kinase entities. These oncogenic modifications alter signal propagation which converge on the gatekeeper kinases MEK1/2,… read more here.
Keywords: phosphorylation; kincon; kinase; activity ... See more keywords