Hyperactive MEK1 Signaling in Cortical GABAergic Neurons Promotes Embryonic Parvalbumin Neuron Loss and Defects in Behavioral Inhibition.
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DOI: 10.1093/cercor/bhaa413
Abstract: Many developmental syndromes have been linked to genetic mutations that cause abnormal ERK/MAPK activity; however, the neuropathological effects of hyperactive signaling are not fully understood. Here, we examined whether hyperactivation of MEK1 modifies the development… read more here.
Keywords: hyperactive mek1; mek1 signaling; neuron; parvalbumin ... See more keywords