Sensitivity to immune checkpoint inhibitors in BRAF/MEK inhibitor refractory melanoma
Sign Up to like & getrecommendations! Published in 2025 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2025-011551
Abstract: Background Resistance to BRAF and MEK inhibitors (BRAFi/MEKi) in metastatic melanoma frequently results in cross-resistance to immune checkpoint inhibitors (ICI), limiting effective treatment options. However, a subset of BRAFi/MEKi-resistant patients remains responsive to second-line ICI,… read more here.
Keywords: resistance; brafi meki; melanoma; meki resistant ... See more keywords
Abstract 1897: Mechanism of MEK inhibitor resistance in triple negative breast cancer
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DOI: 10.1158/1538-7445.am2020-1897
Abstract: Background: Triple-negative breast cancer (TNBC) is an aggressive disease associated with recurrence, metastasis, and resistance to chemotherapy and radiation; effective targeted therapies are needed. Although the MEK inhibitors (MEKi) selumetinib (AZD6244) and pimasertib (AS703026) showed… read more here.
Keywords: resistant cells; meki resistant; inhibitor; mechanism ... See more keywords
Antigen Peptide Transporter 1 (TAP1) Promotes Resistance to MEK Inhibitors in Pancreatic Cancers
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DOI: 10.3390/ijms23137168
Abstract: Mitogen-activated protein kinase (MAPK) kinase (MEK) inhibitors show limited benefit in Kirsten rat sarcoma (KRAS) mutant pancreatic cancer due to drug resistance. To identify mechanisms of resistance to MEK inhibitor (MEKi), we employed a differential… read more here.
Keywords: meki resistant; mek inhibitors; resistance; resistance mek ... See more keywords