Abstract 1897: Mechanism of MEK inhibitor resistance in triple negative breast cancer
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Research"
DOI: 10.1158/1538-7445.am2020-1897
Abstract: Background: Triple-negative breast cancer (TNBC) is an aggressive disease associated with recurrence, metastasis, and resistance to chemotherapy and radiation; effective targeted therapies are needed. Although the MEK inhibitors (MEKi) selumetinib (AZD6244) and pimasertib (AS703026) showed… read more here.
Keywords: resistant cells; meki resistant; inhibitor; mechanism ... See more keywords
Antigen Peptide Transporter 1 (TAP1) Promotes Resistance to MEK Inhibitors in Pancreatic Cancers
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DOI: 10.3390/ijms23137168
Abstract: Mitogen-activated protein kinase (MAPK) kinase (MEK) inhibitors show limited benefit in Kirsten rat sarcoma (KRAS) mutant pancreatic cancer due to drug resistance. To identify mechanisms of resistance to MEK inhibitor (MEKi), we employed a differential… read more here.
Keywords: meki resistant; mek inhibitors; resistance; resistance mek ... See more keywords