Brain-specific TRAF7 deletion ameliorates traumatic brain injury by suppressing MEKK3-regulated glial inflammation and neuronal death.
Sign Up to like & getrecommendations! Published in 2021 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2021.108219
Abstract: Neuronal death and neuroinflammation play critical roles in regulating the progression of traumatic brain injury (TBI). However, associated pathogenesis has not been fully understood. Tumor necrosis factor receptor-associated factor 7 (TRAF7), as the unique noncanonical… read more here.
Keywords: brain specific; mekk3; brain; tbi ... See more keywords
MEKK3 activates IRF7 to trigger a potent type I interferon induction in response to TLR7/9 signaling.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular immunology"
DOI: 10.1016/j.molimm.2021.03.008
Abstract: Interferon regulatory factor 7 (IRF7) is a crucial regulator of type I interferons (IFNs) against pathogen infections and plays a significant role in the endosomal Toll-like receptor signaling (namely, TLR7 and TLR9) in plasmacytoid dendritic… read more here.
Keywords: mekk3; activates irf7; tlr7 signaling; irf7 trigger ... See more keywords
CDC42 Deletion Elicits Cerebral Vascular Malformations via Increased MEKK3-Dependent KLF4 Expression
Sign Up to like & getrecommendations! Published in 2019 at "Circulation Research"
DOI: 10.1161/circresaha.118.314300
Abstract: Rationale: Aberrant formation of blood vessels precedes a broad spectrum of vascular complications; however, the cellular and molecular events governing vascular malformations are not yet fully understood. Objective: Here, we investigated the role of CDC42… read more here.
Keywords: deletion; vascular malformations; kinase; cdc42 ... See more keywords
Release of STK24/25 suppression on MEKK3 signaling in endothelial cells confers cerebral cavernous malformation
Sign Up to like & getrecommendations! Published in 2023 at "JCI Insight"
DOI: 10.1172/jci.insight.160372
Abstract: Loss-of-function mutations in cerebral cavernous malformation (CCM) genes and gain-of-function mutation in the MAP3K3 gene encoding MEKK3 cause CCM. Deficiency of CCM proteins leads to the activation of MEKK3-KLF2/4 signaling, but it is not clear… read more here.
Keywords: ccm; endothelial cells; mekk3; cavernous malformation ... See more keywords
MEKK3 Regulates Angiogenesis through Smad Signaling
Sign Up to like & getrecommendations! Published in 2020 at "Blood"
DOI: 10.1182/blood-2020-143395
Abstract: Angiogenesis is one of the most essential events during embryonic development. The previous studies proved that MEKK3 (MAP3K3) is critical for angiogenesis. However, precisely how MEKK3 regulates the vascular development remains largely unknown. To investigate… read more here.
Keywords: mekk3; angiogenesis; mekk3 iec; endothelial cells ... See more keywords
Endothelial MEKK3-KLF2/4 signaling integrates inflammatory and hemodynamic signals during definitive hematopoiesis.
Sign Up to like & getrecommendations! Published in 2022 at "Blood"
DOI: 10.1182/blood.2021013934
Abstract: The hematopoietic stem cells (HSCs) that produce blood for the lifetime of an animal arise from RUNX1+ hemogenic endothelial cells (HECs) in the embryonic vasculature through a process of endothelial-to-hematopoietic transition (EHT). Studies have identified… read more here.
Keywords: inflammatory mediators; definitive hematopoiesis; mekk3 klf2; mekk3 ... See more keywords
MicroRNA-124 regulates the expression of MEKK3 in the inflammatory pathogenesis of Parkinson’s disease
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Neuroinflammation"
DOI: 10.1186/s12974-018-1053-4
Abstract: BackgroundParkinson’s disease (PD) is the most prevalent neurodegenerative disorder that is characterised by selective loss of midbrain dopaminergic (DA) neurons. Chronic inflammation of the central nervous system is mediated by microglial cells and plays a… read more here.
Keywords: mekk3; microrna 124; model; expression ... See more keywords