Divergent Evolution of Lanthipeptide Stereochemistry
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DOI: 10.1021/acschembio.2c00492
Abstract: The three-dimensional structure of natural products is critical for their biological activities and, as such, enzymes have evolved that specifically generate active stereoisomers. Lanthipeptides are post-translationally modified peptidic natural products that contain macrocyclic thioethers featuring… read more here.
Keywords: evolution lanthipeptide; divergent evolution; melan; lanthipeptide stereochemistry ... See more keywords
Unexpected Methyllanthionine Stereochemistry in the Morphogenetic Lanthipeptide SapT
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DOI: 10.1021/jacs.2c00517
Abstract: Lanthipeptides are polycyclic peptides characterized by the presence of lanthionine (Lan) and/or methyllanthionine (MeLan). They are members of the ribosomally synthesized and post-translationally modified peptides (RiPPs). The stereochemical configuration of (Me)Lan cross-links is important for… read more here.
Keywords: methyllanthionine stereochemistry; melan; stereochemistry; lanthipeptide ... See more keywords