Implications of melanin binding in ocular drug delivery☆
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DOI: 10.1016/j.addr.2017.12.008
Abstract: Abstract Pigmented ocular tissues contain melanin within the intracellular melanosomes. Drugs bind to melanin at varying extent that ranges from no binding to extensive binding. Binding may lead to drug accumulation to the pigmented tissues… read more here.
Keywords: drug; drug delivery; melanin binding; ocular drug ... See more keywords
Understanding Molecular Drivers of Melanin Binding To Support Rational Design of Small Molecule Ophthalmic Drugs.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.8b01281
Abstract: Binding of drugs to ocular melanin is a prominent biological phenomenon that affects the local pharmacokinetics and pharmacodynamics in the eye. In this work, we report on the development of in vitro and in silico… read more here.
Keywords: binding support; melanin; molecular drivers; melanin binding ... See more keywords
Establishment of an In Vitro-In Vivo Correlation for Melanin Binding and the Extension of the Ocular Half-Life of Small Molecule Drugs.
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DOI: 10.1021/acs.molpharmaceut.9b00769
Abstract: A large variety of drugs bind effectively to melanin and this binding influences their ocular pharmacokinetic and distribution profiles. We aimed to establish a correlation between in vitro melanin binding and in vivo ocular pharmacokinetics… read more here.
Keywords: melanin; small molecule; correlation; drug ... See more keywords
Development of a Phototoxicity Testing Strategy for Accurate Photosafety Evaluation of Pharmaceuticals Based on the Assessment of Possible Melanin-Binding Effects
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Toxicology"
DOI: 10.1177/1091581818777998
Abstract: Drug-induced phototoxicity occurs when drugs absorb natural sunlight, leading to chemical reactions causing cellular damage. Distribution to light-exposed tissues is critical and is enhanced by binding to melanin. The International Council on Harmonization S10 guidance… read more here.
Keywords: photosafety evaluation; evaluation pharmaceuticals; melanin; melanin binding ... See more keywords