Melanocortin 5 receptor signaling pathway in health and disease
Sign Up to like & getrecommendations! Published in 2020 at "Cellular and Molecular Life Sciences"
DOI: 10.1007/s00018-020-03511-0
Abstract: Melanocortin hormone system plays a key role in maintaining the homeostasis of our body via their neuro-immune-endocrine activities and regulates a diverse array of physiological functions, including melanogenesis, inflammation, immunomodulation, adrenocortical steroidogenesis, hemodynamics, natriuresis, energy… read more here.
Keywords: disease; mc5r; melanocortin receptor; health ... See more keywords
Bone phenotype in melanocortin 2 receptor-deficient mice
Sign Up to like & getrecommendations! Published in 2020 at "Bone Reports"
DOI: 10.1016/j.bonr.2020.100713
Abstract: Considering that stress condition associated with osteoporosis, the hypothalamic-pituitary-adrenal (HPA) axis, which is essential for central stress response system, is implicated in regulating bone mass accrual. Melanocortin 2 receptor (MC2R), the receptor of adrenocorticotropic hormone… read more here.
Keywords: bone; mc2r mice; mice; melanocortin receptor ... See more keywords
The genetic polymorphisms of melanocortin-4 receptor gene are associated with carcass quality traits in a Chinese indigenous beef cattle breed.
Sign Up to like & getrecommendations! Published in 2020 at "Research in veterinary science"
DOI: 10.1016/j.rvsc.2020.06.011
Abstract: Melanocortin-4 receptor (MC4R) was considered as an essential modifiers in feelings intake, the regulation of metabolism and body weight. This study aimed at identifying polymorphisms in MC4R gene that might associate with carcass quality traits… read more here.
Keywords: quality traits; carcass quality; gene; melanocortin receptor ... See more keywords
Association of the melanocortin 4 receptor (MC4R) gene polymorphism with growth traits of Hu sheep
Sign Up to like & getrecommendations! Published in 2020 at "Small Ruminant Research"
DOI: 10.1016/j.smallrumres.2020.106206
Abstract: Abstract In this study, Single Nucleotide Polymorphisms (SNPs) within the full length of the melanocortin 4 receptor (MC4R) gene in Hu sheep were detected and the functional SNPs associated with growth traits of Hu sheep… read more here.
Keywords: receptor mc4r; mc4r gene; melanocortin receptor; traits sheep ... See more keywords
The melanocortin-2 receptor of the rainbow trout: Identifying a role for critical positions in transmembrane domain 4, extracellular loop 2, and transmembrane domain 5 in the activation of rainbow trout MC2R.
Sign Up to like & getrecommendations! Published in 2018 at "General and comparative endocrinology"
DOI: 10.1016/j.ygcen.2017.05.003
Abstract: The activation of either teleost or tetrapod melanocortin-2 receptor (MC2R) orthologs requires interaction between the HFRW motif and R/KKRRP motif in the primary sequence of ACTH, and two corresponding sites on the melanocortin 2 receptor.… read more here.
Keywords: melanocortin receptor; rainbow trout; transmembrane domain; activation ... See more keywords
Pharmacology of the giant panda (Ailuropoda melanoleuca) melanocortin-3 receptor.
Sign Up to like & getrecommendations! Published in 2019 at "General and comparative endocrinology"
DOI: 10.1016/j.ygcen.2018.10.024
Abstract: The melanocortin-3 receptor (MC3R) is a member of the G protein-coupled receptor superfamily that plays a critical role in controlling energy balance and metabolism. Although pharmacological characterization of MC3R has been reported previously in several… read more here.
Keywords: panda ailuropoda; giant panda; melanocortin receptor; pharmacology ... See more keywords
Orange-spotted grouper melanocortin-4 receptor: modulation of signaling by MRAP2.
Sign Up to like & getrecommendations! Published in 2019 at "General and comparative endocrinology"
DOI: 10.1016/j.ygcen.2019.113234
Abstract: Melanocortin-4 receptor (MC4R) and melanocortin receptor accessory protein 2 (MRAP2) play important roles in the melanocortin system, and interaction of MC4R and MRAP2 is suggested to play pivotal role in energy balance of vertebrates. Orange-spotted… read more here.
Keywords: mc4r mrap2; mc4r; orange spotted; spotted grouper ... See more keywords
Regulation of melanocortin-1 receptor pharmacology by melanocortin receptor accessory protein 2 in orange-spotted grouper (Epinephelus coioides).
Sign Up to like & getrecommendations! Published in 2019 at "General and comparative endocrinology"
DOI: 10.1016/j.ygcen.2019.113291
Abstract: Melanocortin-1 receptor (MC1R) has important roles in regulating pigmentation and inflammation. Melanocortin receptor accessory protein 2 (MRAP2) modulates trafficking, ligand binding, and signaling of mammalian melanocortin receptors. However, the effect of MRAP2 on fish MC1R… read more here.
Keywords: protein; melanocortin receptor; pharmacology; receptor accessory ... See more keywords
Click-Chemistry-Mediated Synthesis of Selective Melanocortin Receptor 4 Agonists.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.7b00353
Abstract: The melanocortin receptor 4 (MC4R) subtype of the melanocortin receptor family is a target for therapeutics to ameliorate metabolic dysfunction. Endogenous MC4R agonists possess a critical pharmacophore (HFRW), and cyclization of peptide agonists often enhances… read more here.
Keywords: click chemistry; mc4r; chemistry; melanocortin receptor ... See more keywords
Structural insights into ligand recognition and activation of the melanocortin-4 receptor.
Sign Up to like & getrecommendations! Published in 2021 at "Cell research"
DOI: 10.1038/s41422-021-00552-3
Abstract: Melanocortin-4 receptor (MC4R) plays a central role in the regulation of energy homeostasis. Its high sequence similarity to other MC receptor family members, low agonist selectivity and the lack of structural information concerning MC4R-specific activation… read more here.
Keywords: mc4r; recognition; melanocortin receptor; activation ... See more keywords
MRAP2 regulates ghrelin receptor signaling and hunger sensing
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/s41467-017-00747-6
Abstract: Ghrelin is the only known circulating orexigenic hormone. It is primarily secreted by the stomach and acts at its receptor, the growth hormone secretagogue receptor 1a (GHSR1a), in the hypothalamus to signal hunger and promote… read more here.
Keywords: ghrelin receptor; regulates ghrelin; hunger; melanocortin receptor ... See more keywords