Genetic and methylation profiles distinguish benign, malignant and spitzoid melanocytic tumors
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Cancer"
DOI: 10.1002/ijc.34187
Abstract: Accurate classification of melanocytic tumors is important for prognostic evaluation, treatment and follow‐up protocols of patients. The majority of melanocytic proliferations can be classified solely based on clinical and pathological criteria, however in select cases… read more here.
Keywords: nevi melanoma; methylation; spitz nevi; melanocytic tumors ... See more keywords
Unclassified sclerosing malignant melanomas with AKAP9-BRAF gene fusion: a report of two cases and review of BRAF fusions in melanocytic tumors
Sign Up to like & getrecommendations! Published in 2017 at "Virchows Archiv"
DOI: 10.1007/s00428-017-2290-0
Abstract: The current classification of melanocytic tumors includes clinical, pathological, and molecular data. A subset of lesions remains difficult to classify according to these complex multilayer schemes. We report two cases of deeply infiltrating melanomas with… read more here.
Keywords: report two; akap9 braf; braf; melanocytic tumors ... See more keywords
Tumor-infiltrating lymphocytes (TILs) in feline melanocytic tumors: A preliminary investigation.
Sign Up to like & getrecommendations! Published in 2021 at "Veterinary immunology and immunopathology"
DOI: 10.1016/j.vetimm.2021.110337
Abstract: The presence and the role of tumor-infiltrating lymphocytes (TILs) in different types of tumors, but particularly in melanoma, has become more and more investigated during the last decade, both in human and veterinary medicine. Melanocytic… read more here.
Keywords: infiltrating lymphocytes; lymphocytes tils; tils feline; melanocytic tumors ... See more keywords
Primary leptomeningeal melanocytic tumors of the spine: report of two cases and review of the literature.
Sign Up to like & getrecommendations! Published in 2019 at "World neurosurgery"
DOI: 10.1016/j.wneu.2019.01.015
Abstract: Primary leptomeningeal melanocytic tumors of the central nervous system are rare and especially in the spine less frequent compared to other entities. There is no consensus regarding the best care of these tumors. We report… read more here.
Keywords: tumors spine; report two; leptomeningeal melanocytic; melanocytic tumors ... See more keywords
Melanocytic tumors with MAP3K8 fusions: report of 33 cases with morphological-genetic correlations
Sign Up to like & getrecommendations! Published in 2019 at "Modern Pathology"
DOI: 10.1038/s41379-019-0384-8
Abstract: We report a series of 33 skin tumors harboring a gene fusion of the MAP3K8 gene, which encodes a serine/threonine kinase. The MAP3K8 fusions were identified by RNA sequencing in 28 cases and by break-apart… read more here.
Keywords: map3k8 fusions; fusions report; melanocytic tumors; tumors map3k8 ... See more keywords
Update on classification of melanocytic tumors and the role of immunohistochemistry and molecular techniques.
Sign Up to like & getrecommendations! Published in 2022 at "Seminars in diagnostic pathology"
DOI: 10.1053/j.semdp.2022.02.001
Abstract: The nine pathways to melanoma outlined in the most recent WHO classification of skin tumors attempt to capture the typical evolution of different subtypes of melanoma as governed by cell of origin, mutagenic factors and… read more here.
Keywords: molecular techniques; update classification; melanocytic tumors; classification ... See more keywords
Performance of PRAME immunohistochemistry compared with that of c‐Kit, c‐Myc, or cyclin D1 for the diagnosis of acral melanocytic tumors
Sign Up to like & getrecommendations! Published in 2022 at "Pathology International"
DOI: 10.1111/pin.13292
Abstract: The diagnostic role of preferentially expressed antigen in melanoma (PRAME) immunohistochemistry has not been thoroughly evaluated for acral melanocytic tumors. The objective of this study was to evaluate the utility of this modality for the… read more here.
Keywords: sampus; acral melanocytic; prame immunohistochemistry; melanocytic tumors ... See more keywords
Integrated Genomic Classification of Melanocytic Tumors of the Central Nervous System Using Mutation Analysis, Copy Number Alterations, and DNA Methylation Profiling
Sign Up to like & getrecommendations! Published in 2018 at "Clinical Cancer Research"
DOI: 10.1158/1078-0432.ccr-18-0763
Abstract: Purpose: In the central nervous system, distinguishing primary leptomeningeal melanocytic tumors from melanoma metastases and predicting their biological behavior solely using histopathologic criteria may be challenging. We aimed to assess the diagnostic and prognostic value… read more here.
Keywords: melanocytic tumors; nervous system; central nervous; dna methylation ... See more keywords