NDUFS7 variant in dogs with Leigh syndrome and its functional validation in a Drosophila melanogaster model
Sign Up to like & getrecommendations! Published in 2024 at "Scientific Reports"
DOI: 10.1038/s41598-024-53314-7
Abstract: Two Jack-Russell Terrier × Chihuahua mixed-breed littermates with Leigh syndrome were investigated. The dogs presented with progressive ataxia, dystonia, and increased lactate levels. Brain MRI showed characteristic bilateral symmetrical T2 hyperintense lesions, histologically representing encephalomalacia.… read more here.
Keywords: leigh syndrome; model; melanogaster model; drosophila melanogaster ... See more keywords
Differential effects of phytotherapic preparations in the hSOD1 Drosophila melanogaster model of ALS
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/srep41059
Abstract: The present study was aimed at characterizing the effects of Withania somnifera (Wse) and Mucuna pruriens (Mpe) on a Drosophila melanogaster model for Amyotrophic Lateral Sclerosis (ALS). In particular, the effects of Wse and Mpe… read more here.
Keywords: wse mpe; differential effects; drosophila melanogaster; model ... See more keywords
Dietary inclusions of Solanum vegetables mitigate aluminum-induced redox and inflammation-related neurotoxicity in Drosophila melanogaster model.
Sign Up to like & getrecommendations! Published in 2021 at "Nutritional neuroscience"
DOI: 10.1080/1028415x.2021.1933331
Abstract: BACKGROUND This study investigated the modulatory capacity of two Solanum green leafy vegetables; S. macrocarpon L. (African eggplant AE) and S. nigrum L. (Black nightshade BN) on dysregulation of some antioxidant, pro-apoptotic, pro-inflammatory-like, acetylcholinesterase gene… read more here.
Keywords: neurotoxicity; dietary inclusions; drosophila melanogaster; melanogaster model ... See more keywords
Neuroprotective properties of solanum leaves in transgenic Drosophila melanogaster model of Alzheimer's disease
Sign Up to like & getrecommendations! Published in 2022 at "Biomarkers"
DOI: 10.1080/1354750x.2022.2077446
Abstract: Abstract Introduction We investigated the effect of African eggplant (AE) (Solanum macrocarpon L) and Black nightshade (BN) (Solanum nigrum L) leaves; two tropical vegetables consumed by humans on behavioural, biochemical and histological indices in Drosophila… read more here.
Keywords: model alzheimer; alzheimer disease; neuroprotective properties; melanogaster model ... See more keywords
Controlled decoration of nanoceria on the surface of MoS2 nanoflowers to improve the biodegradability and biocompatibility in Drosophila melanogaster model
Sign Up to like & getrecommendations! Published in 2022 at "Nanotechnology"
DOI: 10.1088/1361-6528/ac4fe4
Abstract: In recent years, nanozymes based on two-dimensional (2D) nanomaterials have been receiving great interest for cancer photothermal therapy. 2D materials decorated with nanoparticles (NPs) on their surface are advantageous over conventional NPs and 2D material… read more here.
Keywords: mos2 nfs; biocompatibility; mos2; decoration ... See more keywords
Drosophila melanogaster as a model arthropod carrier for the amphibian chytrid fungus Batrachochytrium dendrobatidis
Sign Up to like & getrecommendations! Published in 2024 at "PLOS ONE"
DOI: 10.1371/journal.pone.0307833
Abstract: The fungal pathogen Batrachochytrium dendrobatidis (Bd) causes the disease amphibian chytridiomycosis, which has contributed to population declines in many species of amphibians throughout the world. Previous observational studies have shown that nematodes, waterfowl, lizards, other… read more here.
Keywords: batrachochytrium dendrobatidis; carrier; melanogaster model; drosophila melanogaster ... See more keywords
Drosophila melanogaster as a model for unraveling unique molecular features of epilepsy elicited by human GABA transporter 1 variants
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Neuroscience"
DOI: 10.3389/fnins.2022.1074427
Abstract: Mutations in the human γ-aminobutyric acid (GABA) transporter 1 (hGAT-1) can instigate myoclonic-atonic and other generalized epilepsies in the afflicted individuals. We systematically examined fifteen hGAT-1 disease variants, all of which dramatically reduced or completely… read more here.
Keywords: gaba transporter; model unraveling; gaba; melanogaster model ... See more keywords
Drosophila melanogaster as a model to study autophagy in neurodegenerative diseases induced by proteinopathies
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Neuroscience"
DOI: 10.3389/fnins.2023.1082047
Abstract: Proteinopathies are a large group of neurodegenerative diseases caused by both genetic and sporadic mutations in particular genes which can lead to alterations of the protein structure and to the formation of aggregates, especially toxic… read more here.
Keywords: neurodegenerative diseases; study autophagy; model study; autophagy neurodegenerative ... See more keywords
Drosophila melanogaster as a Model to Study Fragile X-Associated Disorders
Sign Up to like & getrecommendations! Published in 2022 at "Genes"
DOI: 10.3390/genes14010087
Abstract: Fragile X syndrome (FXS) is a global neurodevelopmental disorder caused by the expansion of CGG trinucleotide repeats (≥200) in the Fragile X Messenger Ribonucleoprotein 1 (FMR1) gene. FXS is the hallmark of Fragile X-associated disorders… read more here.
Keywords: fragile associated; associated disorders; model; melanogaster model ... See more keywords