Vegetable‐derived indole enhances the melanoma‐treating efficacy of chemotherapeutics
Sign Up to like & getrecommendations! Published in 2022 at "Phytotherapy Research"
DOI: 10.1002/ptr.7565
Abstract: Food‐drug interaction is an important but overlooked issue. For example, little is known concerning whether or not the chemotherapy of cancers is affected by the well‐defined dietary chemicals such as 2‐(indol‐3‐ylmethyl)‐3,3′‐diindolylmethane (LTr1) derived from daily… read more here.
Keywords: derived indole; indole enhances; vegetable derived; melanogenesis ... See more keywords
Triterpenoid saponins from Polaskia chichipe Backbg. and their inhibitory or promotional effects on the melanogenesis of B16 melanoma cells
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Natural Medicines"
DOI: 10.1007/s11418-017-1082-9
Abstract: Five new oleanane-type saponins 1–5 together with a known saponin 6 and a steroidal glycoside 7 were isolated from Polaskia chichipe Backbg., and their structures were determined from their 1D and 2D NMR and HRFABMS… read more here.
Keywords: effects melanogenesis; chichipe backbg; b16 melanoma; polaskia chichipe ... See more keywords
The role of sex-determining region Y-box 6 in melanogenesis in alpaca melanocytes.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of dermatological science"
DOI: 10.1016/j.jdermsci.2018.05.007
Abstract: BACKGROUND Sex-determining region Y-box (SOX) proteins function as transcriptional regulators. The derivation of melanocytes from nerve crest cells has been reported to depend on SOX proteins, including SOX10 and SOX5. Whether SOX6 is expressed and… read more here.
Keywords: region box; cyclin; role; sex determining ... See more keywords
Ethyl acetate extract from Panax ginseng C.A. Meyer and its main constituents inhibit α-melanocyte-stimulating hormone-induced melanogenesis by suppressing oxidative stress in B16 mouse melanoma cells.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of ethnopharmacology"
DOI: 10.1016/j.jep.2017.07.004
Abstract: ETHNOPHARMACOLOGICAL RELEVANCE Hyperpigmentation disease involves darkening of the skin color due to melanin overproduction. Panax ginseng C.A. Meyer is a well-known traditional Chinese medicine and has a long history of use as a skin lightener… read more here.
Keywords: panax ginseng; melanogenesis; ginseng meyer;
ABCB6 Resides in Melanosomes and Regulates Early Steps of Melanogenesis Required for PMEL Amyloid Matrix Formation.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2018.06.033
Abstract: Genetically inheritable pigmentation defects provide a unique opportunity to reveal the function of proteins contributing to melanogenesis. Dyschromatosis universalis hereditaria (DUH) is a rare pigmentary genodermatosis associated with mutations in the ABCB6 gene. Here we… read more here.
Keywords: abcb6; matrix formation; formation; abcb6 resides ... See more keywords
IDH2 deficiency accelerates skin pigmentation in mice via enhancing melanogenesis
Sign Up to like & getrecommendations! Published in 2018 at "Redox Biology"
DOI: 10.1016/j.redox.2018.04.008
Abstract: Melanogenesis is a complex biosynthetic pathway regulated by multiple agents, which are involved in the production, transport, and release of melanin. Melanin has diverse roles, including determination of visible skin color and photoprotection. Studies indicate… read more here.
Keywords: melanogenesis; idh2 deficiency; mice; pigmentation ... See more keywords
Advances in the Design of Genuine Human Tyrosinase Inhibitors for Targeting Melanogenesis and Related Pigmentations.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.0c00994
Abstract: Human tyrosinase (hsTYR) is the key enzyme ensuring the conversion of L-tyrosine to dopaqui-none, thereby initiating melanin synthesis, i.e. melanogenesis. Although the protein has long been familiar, knowledge about its three-dimensional structure and efficient overexpression… read more here.
Keywords: tyrosinase inhibitors; chemistry; tyrosinase; advances design ... See more keywords
Selaginellin Inhibits Melanogenesis via the MAPK Signaling Pathway.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of natural products"
DOI: 10.1021/acs.jnatprod.1c00971
Abstract: Hyperpigmented skin diseases such as melasma, freckles, and melanosis usually mar the appearance of patients. Traditional herbal medicines are highly accepted in inhibiting skin pigmentation, with advantages of high efficiency, low cost, and low side… read more here.
Keywords: signaling pathway; mapk signaling; inhibits melanogenesis; selaginellin inhibits ... See more keywords
Characterization of Caffeoylquinic Acids from Lepisorus thunbergianus and Their Melanogenesis Inhibitory Activity
Sign Up to like & getrecommendations! Published in 2020 at "ACS Omega"
DOI: 10.1021/acsomega.0c03752
Abstract: Hyperpigmentation resulting from the overactivation of tyrosinase leads to darker spots or patches on the human skin. Although these phenomena are harmless, there is still great demand for melanogenesis inhibitors to prevent hyperpigmentation by inhibiting… read more here.
Keywords: inhibitory; tyrosinase; melanogenesis; activity ... See more keywords
Beauvericin inhibits melanogenesis by regulating cAMP/PKA/CREB and LXR-α/p38 MAPK–mediated pathways
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-33352-8
Abstract: Melanogenesis is the process of production of melanin pigments that are responsible for the colors of skin, eye, and hair and provide protection from ultraviolet radiation. However, excessive levels of melanin formation cause hyperpigmentation disorders… read more here.
Keywords: pka creb; melanogenesis; camp pka; p38 mapk ... See more keywords
Local epidermal growth factor delivery using nanopillared chitosan-gelatin films for melanogenesis and wound healing.
Sign Up to like & getrecommendations! Published in 2022 at "Biomaterials science"
DOI: 10.1039/d2bm00836j
Abstract: Epidermal growth factor (EGF) is required for various regulations of skin tissue including wound healing; however, it has limited stability due to the physicochemical conditions of the wound milieu. The lack of functional EGF within… read more here.
Keywords: wound healing; epidermal growth; chitosan gelatin; growth factor ... See more keywords