STAT3 inhibitor Napabucasin abrogates MDSC immunosuppressive capacity and prolongs survival of melanoma-bearing mice
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DOI: 10.1136/jitc-2021-004384
Abstract: Background Myeloid-derived suppressor cells (MDSCs) represent a negative prognostic factor in malignant melanoma. These cells are generated under chronic inflammatory conditions typical of cancer. The transcription factor signal transducer and activator of transcription 3 (STAT3)… read more here.
Keywords: capacity; stat3; melanoma bearing; mdsc ... See more keywords