The impact of current treatment modalities on the outcomes of patients with melanoma brain metastases: A systematic review
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Cancer"
DOI: 10.1002/ijc.32696
Abstract: Patients with melanoma brain metastases (MBM) still have a very poor prognosis. Several treatment modalities have been investigated in an attempt to improve the management of MBM. This review aimed to evaluate the impact of… read more here.
Keywords: brain metastases; treatment modalities; treatment; therapy ... See more keywords
Extent of surrounding edema does not correlate with acute complications after radiosurgery for melanoma brain metastases
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Neuro-Oncology"
DOI: 10.1007/s11060-019-03330-9
Abstract: To assess whether extent of surrounding edema correlates with acute adverse clinical outcomes within 3 months after stereotactic radiosurgery (SRS) for melanoma brain metastases (BM). Patients with melanoma BM treated with SRS were included in… read more here.
Keywords: surrounding edema; volume; extent surrounding; edema ... See more keywords
Current Treatment of Melanoma Brain Metastasis
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DOI: 10.1007/s11864-020-00733-z
Abstract: With greater understanding of underlying biology and development of effective BRAF-targeted therapy and immunotherapy, along with remarkable advances in local treatment such as stereotactic radiosurgery, melanoma brain metastasis (MBM) is witnessing continually improving outcome, with… read more here.
Keywords: treatment; melanoma brain; brain; brain metastasis ... See more keywords
Inflammatory Activation of Astrocytes Facilitates Melanoma Brain Tropism via the CXCL10-CXCR3 Signaling Axis.
Sign Up to like & getrecommendations! Published in 2019 at "Cell reports"
DOI: 10.1016/j.celrep.2019.07.033
Abstract: Melanoma is the deadliest skin cancer due to its high rate of metastasis, frequently to the brain. Brain metastases are incurable; therefore, understanding melanoma brain metastasis is of great clinical importance. We used a mouse… read more here.
Keywords: melanoma; cxcr3; metastasis; cxcl10 ... See more keywords
Survival of patients with melanoma brain metastasis treated with stereotactic radiosurgery and active systemic drug therapies.
Sign Up to like & getrecommendations! Published in 2017 at "European journal of cancer"
DOI: 10.1016/j.ejca.2017.01.007
Abstract: INTRODUCTION With new systemic therapies demonstrating activity in melanoma brain metastasis, most of the previously reported stereotactic radiosurgery (SRS) data are superseded. In this study, we report the outcomes (overall survival [OS] and brain control [BC]) and… read more here.
Keywords: melanoma brain; stereotactic radiosurgery; brain; brain metastasis ... See more keywords
Real-life data for first-line combination immune-checkpoint inhibition and targeted therapy in patients with melanoma brain metastases.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of cancer"
DOI: 10.1016/j.ejca.2021.07.028
Abstract: BACKGROUND Melanoma brain metastases (MBM) have a poor prognosis. Systemic treatments that have improved outcomes in advanced melanoma have been shown to have an intracranial (IC) effect. We studied the efficacy and outcomes of combined immune… read more here.
Keywords: combi ici; first line; combi; melanoma brain ... See more keywords
Drug delivery to melanoma brain metastases: Can current challenges lead to new opportunities?
Sign Up to like & getrecommendations! Published in 2017 at "Pharmacological research"
DOI: 10.1016/j.phrs.2017.06.008
Abstract: Melanoma has a high propensity to metastasize to the brain, and patients with melanoma brain metastases (MBM) have an extremely poor prognosis. The recent approval of several molecularly-targeted agents (e.g., BRAF, MEK inhibitors) and biologics… read more here.
Keywords: brain metastases; delivery; drug; resistance ... See more keywords
CMET-23. IMPACT OF SYSTEMIC THERAPY IN MELANOMA BRAIN METASTASIS
Sign Up to like & getrecommendations! Published in 2019 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noz175.224
Abstract: Melanoma is the third most common malignancy that results in brain metastasis and is associated with a median overall survival (OS) of approximately 9 months. In recent years, management of melanoma brain metastases (MBM) by… read more here.
Keywords: systemic therapy; brain metastasis; therapy; melanoma brain ... See more keywords
Clinical, dermoscopic, and confocal features of nevi and melanomas in a multiple primary melanoma patient with the MITF p.E318K homozygous mutation.
Sign Up to like & getrecommendations! Published in 2018 at "Melanoma Research"
DOI: 10.1097/cmr.0000000000000427
Abstract: Vemurafenib and radiation therapy in melanoma brain metastases. J Neurooncol 2013; 113:411–416. 5 Gaudy-Marqueste C, Carron R, Delsanti C, Loundou A, Monestier S, Archier E, et al. On demand Gamma-Knife strategy can be safely combined… read more here.
Keywords: melanoma; brain metastases; cancer; melanoma brain ... See more keywords
Real-world data on melanoma brain metastases and survival outcome
Sign Up to like & getrecommendations! Published in 2022 at "Melanoma Research"
DOI: 10.1097/cmr.0000000000000816
Abstract: Novel medical therapies have revolutionized outcome for patients with melanoma. However, patients with melanoma brain metastases (MBM) still have poor survival. Data are limited as these patients are generally excluded from clinical trials, wherefore real-world… read more here.
Keywords: melanoma brain; brain metastases; world data; brain ... See more keywords
Stereotactic radiosurgery for melanoma brain metastases: Concurrent immune checkpoint inhibitor therapy associated with superior clinicoradiological response outcomes
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medical Imaging and Radiation Oncology"
DOI: 10.1111/1754-9485.13403
Abstract: This study assessed long‐term clinical and radiological outcomes following treatment with combination stereotactic radiosurgery (SRS) and immunotherapy (IT) for melanoma brain metastases (BM). read more here.
Keywords: melanoma brain; brain metastases; stereotactic radiosurgery;