Arginyl‐tRNA‐protein transferase 1 (ATE1) promotes melanoma cell growth and migration
Sign Up to like & getrecommendations! Published in 2022 at "FEBS Letters"
DOI: 10.1002/1873-3468.14376
Abstract: Arginyl‐tRNA‐protein transferase 1 (ATE1) catalyses N‐terminal protein arginylation, a post‐translational modification implicated in cell migration, invasion and the cellular stress response. Herein, we report that ATE1 is overexpressed in NRAS‐mutant melanomas, while it is downregulated… read more here.
Keywords: cell; arginyl trna; melanoma cell; ate1 ... See more keywords
Candidate therapeutic agents in a newly established triple wild‐type mucosal melanoma cell line
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Communications"
DOI: 10.1002/cac2.12315
Abstract: Mucosal melanoma has characteristically distinct genetic features and typically poor prognosis. The lack of representative mucosal melanoma models, especially cell lines, has hindered translational research on this melanoma subtype. In this study, we aimed to… read more here.
Keywords: mucosal melanoma; melanoma cell; cell line; melanoma ... See more keywords
Authentication of M14 melanoma cell line proves misidentification of MDA‐MB‐435 breast cancer cell line
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Cancer"
DOI: 10.1002/ijc.31067
Abstract: A variety of analytical approaches have indicated that melanoma cell line UCLA‐SO‐M14 (M14) and breast carcinoma cell line MDA‐MB‐435 originate from a common donor. This indicates that at some point in the past, one of… read more here.
Keywords: melanoma cell; cell line; mda 435; m14 ... See more keywords
The aryl hydrocarbon receptor promotes inflammation‐induced dedifferentiation and systemic metastatic spread of melanoma cells
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Cancer"
DOI: 10.1002/ijc.33252
Abstract: The aryl hydrocarbon receptor (AHR) is a ligand binding‐transcription factor of the basic helix‐loop‐helix family regulating multiple cellular functions such as differentiation, cell cycle, apoptosis, and inflammatory reactions. In neoplastic diseases, the AHR has been… read more here.
Keywords: melanoma; ahr; melanoma cell; inflammation induced ... See more keywords
Lidocaine inhibits melanoma cell proliferation by regulating ERK phosphorylation
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.27927
Abstract: The melanoma is responsible for the majority of all skin cancer–related deaths worldwide. Evidence suggests that local anesthetics provide some benefit in the treatment of cancer via inhibition of cellular proliferation, invasion and migration. However,… read more here.
Keywords: melanoma cell; erk phosphorylation; cell proliferation; proliferation ... See more keywords
Arginase‐II promotes melanoma migration and adhesion through enhancing hydrogen peroxide production and STAT3 signaling
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.29814
Abstract: Elevated arginase type II (Arg‐II) associates with higher grade tumors. Its function and underlying molecular mechanisms in melanoma remain elusive. In the present study, we observed a significantly higher frequency of Arg‐II expression in melanoma… read more here.
Keywords: melanoma cell; migration adhesion; cell;
Activation of the tumor suppressive Hippo pathway by triptonide as a new strategy to potently inhibit aggressive melanoma cell metastasis.
Sign Up to like & getrecommendations! Published in 2021 at "Biochemical pharmacology"
DOI: 10.1016/j.bcp.2021.114423
Abstract: Metastatic melanoma has a very high mortality rate despite the availability of chemotherapy, radiotherapy, and immunotherapy; therefore, more effective therapeutics are needed. The Hippo pathway plays an inhibitory role in melanoma progression, but the tumor… read more here.
Keywords: melanoma; melanoma cell; metastasis; hippo pathway ... See more keywords
Signatures of protein expression revealed by secretome analyses of cancer associated fibroblasts and melanoma cell lines.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of proteomics"
DOI: 10.1016/j.jprot.2017.12.013
Abstract: The imbalance of cellular homeostasis during oncogenesis together with the high heterogeneity of tumor-associated stromal cells have a marked effect on the repertoire of the proteins secreted by malignant cells (the secretome). Hence, the study… read more here.
Keywords: protein expression; melanoma cell; cell lines; expression ... See more keywords
CircHIPK3 regulates melanoma cell behaviors by binding with miR-215-5p to upregulate YY1.
Sign Up to like & getrecommendations! Published in 2020 at "Molecular and cellular probes"
DOI: 10.1016/j.mcp.2020.101644
Abstract: OBJECT To investigate the role of circHIPK3 in melanoma. METHODS Bioinformatics analysis and experiments including RT-qPCR, Pearson's correlation analysis, luciferase reporter, Western blot, and RIP assays were applied to explore the function and mechanism of… read more here.
Keywords: melanoma cell; cell; mir 215; circhipk3 ... See more keywords
KLF4 is regulated by RAS/RAF/MEK/ERK signaling through E2F1 and promotes melanoma cell growth
Sign Up to like & getrecommendations! Published in 2017 at "Oncogene"
DOI: 10.1038/onc.2016.481
Abstract: Melanoma is the most lethal form of skin cancer and treatment of metastatic melanoma remains challenging. BRAF/MEK inhibitors show only temporary benefit due the occurrence of resistance and immunotherapy is effective only in a subset… read more here.
Keywords: melanoma; klf4; cell growth; melanoma cell ... See more keywords
CD271 determines migratory properties of melanoma cells
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-10129-z
Abstract: Melanoma cell expression of the nerve growth factor receptor CD271 is associated with stem-like properties. However, the contributing role of the receptor in melanoma cell migration is elusive. Here, we explored extracranial (skin, soft tissue,… read more here.
Keywords: melanoma; melanoma cell; cd271; migration ... See more keywords