Melanoma‐derived extracellular vesicles mediate lymphatic remodelling and impair tumour immunity in draining lymph nodes
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Extracellular Vesicles"
DOI: 10.1002/jev2.12197
Abstract: Abstract Tumour‐draining lymph nodes (LNs) undergo massive remodelling including expansion of the lymphatic sinuses, a process that has been linked to lymphatic metastasis by creation of a pre‐metastatic niche. However, the signals leading to these… read more here.
Keywords: derived extracellular; extracellular vesicles; vesicles mediate; draining lymph ... See more keywords
Real-World EQ-5D-5L Utility Values In Patients With Melanoma Derived Using A Digital ‘Bring Your Own Device’ Platform
Sign Up to like & getrecommendations! Published in 2018 at "Value in Health"
DOI: 10.1016/j.jval.2018.04.301
Abstract: New treatments in melanoma are gradually transforming the disease into a chronic condition: • For advanced disease stages, the median survival has significantly increased (from 9 months in stage 4 patients with limited treatment options,… read more here.
Keywords: real world; world utility; utility values; melanoma derived ... See more keywords
Melanoma-Derived iPCCs Show Differential Tumorigenicity and Therapy Response
Sign Up to like & getrecommendations! Published in 2017 at "Stem Cell Reports"
DOI: 10.1016/j.stemcr.2017.03.007
Abstract: Summary A point mutation in the BRAF gene, leading to a constitutively active form of the protein, is present in 45%–60% of patients and acts as a key driver in melanoma. Shortly after therapy induction,… read more here.
Keywords: melanoma; melanoma derived; tumorigenicity; derived ipccs ... See more keywords
Effects of Cyclooxygenase-2 in Canine Melanoma-derived Extracellular Vesicles on Tumor Microenvironment In Vitro
Sign Up to like & getrecommendations! Published in 2022 at "AntiCancer Research"
DOI: 10.21873/anticanres.16044
Abstract: Abstract Background/Aim: Tumor cell-derived extracellular vesicles (TEVs) promote tumor growth and metastasis; thus, they have drawn the attention of researchers. TEVs regulate the tumor microenvironment by facilitating crosstalk between immune and stromal cells. Macrophages are… read more here.
Keywords: canine melanoma; melanoma; derived extracellular; melanoma derived ... See more keywords
Human Melanoma-Derived Extracellular Vesicles Regulate Dendritic Cell Maturation
Sign Up to like & getrecommendations! Published in 2017 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2017.00358
Abstract: Evolution of melanoma from a primary tumor to widespread metastasis is crucially dependent on lymphatic spread. The mechanisms regulating the initial step in metastatic dissemination via regional lymph nodes remain largely unknown; however, evidence supporting… read more here.
Keywords: melanoma; derived extracellular; melanoma derived; cell maturation ... See more keywords
In Vitro Interaction of Melanoma-Derived Extracellular Vesicles with Collagen
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24043703
Abstract: Extracellular vesicles are now considered as active contributors to melanoma progression through their capacity to modify the tumor microenvironment and to favor the formation of a pre-metastatic niche. These prometastatic roles of tumor-derived EVs would… read more here.
Keywords: interaction melanoma; extracellular vesicles; melanoma; melanoma derived ... See more keywords