RAC1P29S Induces a Mesenchymal Phenotypic Switch via Serum Response Factor to Promote Melanoma Development and Therapy Resistance
Sign Up to like & getrecommendations! Published in 2019 at "Cancer Cell"
DOI: 10.1016/j.ccell.2019.05.015
Abstract: Summary RAC1 P29 is the third most commonly mutated codon in human cutaneous melanoma, after BRAF V600 and NRAS Q61. Here, we study the role of RAC1P29S in melanoma development and reveal that RAC1P29S activates… read more here.
Keywords: melanoma; mesenchymal phenotypic; rac1p29s; resistance ... See more keywords
AMBRA1 has an impact on melanoma development beyond autophagy
Sign Up to like & getrecommendations! Published in 2021 at "Autophagy"
DOI: 10.1080/15548627.2021.1940608
Abstract: ABSTRACT AMBRA1 (autophagy/beclin 1 regulator 1) is a multifunctional scaffold protein involved in several cellular processes spanning from cell proliferation to apoptosis and to regulation of macroautophagy/autophagy. Our recent publication revealed that Ambra1 has an… read more here.
Keywords: melanoma; autophagy ambra1; beyond autophagy; impact melanoma ... See more keywords
Circ_0081054 facilitates melanoma development via sponging miR‐637 and regulating RAB9A
Sign Up to like & getrecommendations! Published in 2023 at "Skin Research and Technology"
DOI: 10.1111/srt.13313
Abstract: Accumulating evidence announces that aberrantly expressed circRNAs were closely related to the development of human cancers. However, the role and mechanism of multiple circRNAs remain unclear. Our work aimed to disclose the functional role and… read more here.
Keywords: melanoma development; development; 0081054 facilitates; circ 0081054 ... See more keywords
Deregulation of miR-183 promotes melanoma development via lncRNA MALAT1 regulation and ITGB1 signal activation
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.13862
Abstract: Dysregulation of miR-183 has been recently elucidated in several carcinomas. However, the expression patterns and mechanisms of miR-183 involved in malignant melanoma remain unidentified. Here, we found down-regulation of miR-183 in melanoma tissues and cells.… read more here.
Keywords: mir 183; melanoma development; regulation; malat1 ... See more keywords
Genetic Alterations in the INK4a/ARF Locus: Effects on Melanoma Development and Progression
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DOI: 10.3390/biom10101447
Abstract: Genetic alterations in the INK4a/ARF (or CDKN2A) locus have been reported in many cancer types, including melanoma; head and neck squamous cell carcinomas; lung, breast, and pancreatic cancers. In melanoma, loss of function CDKN2A alterations… read more here.
Keywords: alterations ink4a; cdkn2a; genetic alterations; ink4a arf ... See more keywords
Mutational Characterization of Cutaneous Melanoma Supports Divergent Pathways Model for Melanoma Development
Sign Up to like & getrecommendations! Published in 2021 at "Cancers"
DOI: 10.3390/cancers13205219
Abstract: Simple Summary The divergent pathway model established at least two approaches for melanoma development. One was related to a propensity to melanocytic proliferation (nevogenic), and the other was associated with an accumulation of solar damage… read more here.
Keywords: melanoma; csd melanomas; divergent; model ... See more keywords