The Anthelmintic Flubendazole Blocks Human Melanoma Growth and Metastasis and Suppresses Programmed Cell Death Protein-1 and Myeloid-Derived Suppressor Cell Accumulation.
Sign Up to like & getrecommendations! Published in 2019 at "Cancer letters"
DOI: 10.1016/j.canlet.2019.05.026
Abstract: The incidence of melanoma is increasing faster than any other cancer. In recent years, treatment of melanoma and a range of other deadly cancers has involved immunotherapy with programmed cell death protein-1 (PD-1)/PD-1 ligand (PD-L1)… read more here.
Keywords: melanoma; melanoma growth; flubendazole; programmed cell ... See more keywords
Ku80 promotes melanoma growth and regulates antitumor effect of melatonin by targeting HIF1-α dependent PDK-1 signaling pathway
Sign Up to like & getrecommendations! Published in 2019 at "Redox Biology"
DOI: 10.1016/j.redox.2019.101197
Abstract: Melanoma is one of the most malignant and aggressive cancers with high cancer-related deaths. However, it is unclear whether Ku80 regulates tumor growth in human melanoma. In this study, we screened a siRNA library targeting… read more here.
Keywords: melanoma; melanoma growth; pdk; ku80 ... See more keywords
ERK5 is activated by oncogenic BRAF and promotes melanoma growth
Sign Up to like & getrecommendations! Published in 2018 at "Oncogene"
DOI: 10.1038/s41388-018-0164-9
Abstract: Malignant melanoma is among the most aggressive cancers and its incidence is increasing worldwide. Targeted therapies and immunotherapy have improved the survival of patients with metastatic melanoma in the last few years; however, available treatments… read more here.
Keywords: melanoma; melanoma growth; braf; oncogenic braf ... See more keywords
PSPH promotes melanoma growth and metastasis by metabolic-deregulation–mediated transcriptional activation of NR4A1
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DOI: 10.1038/s41388-021-01683-y
Abstract: Metabolic deregulation, a hallmark of cancer, fuels cancer cell growth and metastasis. Here, we show that phosphoserine phosphatase (PSPH), an enzyme of the serine metabolism pathway, is upregulated in patient-derived melanoma samples. PSPH knockdown using… read more here.
Keywords: melanoma growth; growth; expression; psph ... See more keywords
Aberrant SIRT6 expression contributes to melanoma growth: Role of the autophagy paradox and IGF-AKT signaling
Sign Up to like & getrecommendations! Published in 2018 at "Autophagy"
DOI: 10.1080/15548627.2017.1384886
Abstract: ABSTRACT Melanoma is among the most life-threatening cancers. The pathogenesis of melanoma has not been fully elucidated. Recently, dysregulated macroautophagy/autophagy has been found to play a critical but inconsistent role in modulating melanoma growth at… read more here.
Keywords: melanoma; melanoma growth; expression; autophagy ... See more keywords
α-adrenoceptor stimulation attenuates melanoma growth in mice.
Sign Up to like & getrecommendations! Published in 2021 at "British journal of pharmacology"
DOI: 10.1111/bph.15731
Abstract: BACKGROUND AND PURPOSE Recently, β-adrenoceptor blockade has emerged as a potential strategy to inhibit melanoma growth. However, it remains to be ascertained whether β-adrenoceptor stimulation by circulating catecholamines increases melanoma growth in mice. EXPERIMENTAL APPROACH… read more here.
Keywords: melanoma growth; growth mice; stimulation; adrenoceptor ... See more keywords
ATP-Citrate Lyase Epigenetically Potentiates Oxidative Phosphorylation to Promote Melanoma Growth and Adaptive Resistance to MAPK Inhibition
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DOI: 10.1158/1078-0432.ccr-19-1359
Abstract: Purpose: Enhanced lipogenesis and mitochondrial function are two critical metabolic characteristics in melanoma, but their crosstalk involved in tumor biology and targeted therapy remains unknown. ATP-citrate lyase (ACLY) is a crucial lipogenic enzyme that is… read more here.
Keywords: biology; melanoma growth; melanoma; inhibition ... See more keywords
UTRN inhibits melanoma growth by suppressing p38 and JNK/c-Jun signaling pathways
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DOI: 10.1186/s12935-021-01768-4
Abstract: Background Utrophin (UTRN), as a tumor suppressor gene, is involved in various cancer progression. The function of UTRN in the melanoma process and the related molecular mechanisms are still unclear. Herein, we studied the function… read more here.
Keywords: melanoma; melanoma growth; jun; utrn expression ... See more keywords
XIAP promotes melanoma growth by inducing tumour neutrophil infiltration
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DOI: 10.15252/embr.202153608
Abstract: Elevated expression of the X‐linked inhibitor of apoptosis protein (XIAP) has been frequently reported in malignant melanoma suggesting that XIAP renders apoptosis resistance and thereby supports melanoma progression. Independent of its anti‐apoptotic function, XIAP mediates… read more here.
Keywords: neutrophil infiltration; xiap; melanoma; tumour neutrophil ... See more keywords
A Mixture of Polyunsaturated Fatty Acids ω-3 and ω-6 Reduces Melanoma Growth by Inhibiting Inflammatory Mediators in the Murine Tumor Microenvironment
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DOI: 10.3390/ijms20153765
Abstract: Background: Although it has been previously demonstrated that acute inflammation can promote the tumor growth of a sub-tumorigenic dose of melanoma cells through of 5-lipoxygenase inflammatory pathway and its product leukotriene B4, and also that… read more here.
Keywords: melanoma growth; mixture; growth; oil ... See more keywords
Extracellular Matrix Remodeling by Fibroblast-MMP14 Regulates Melanoma Growth
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DOI: 10.3390/ijms222212276
Abstract: Maintaining a balanced state in remodeling the extracellular matrix is crucial for tissue homeostasis, and this process is altered during skin cancer progression. In melanoma, several proteolytic enzymes are expressed in a time and compartmentalized… read more here.
Keywords: collagen; melanoma growth; extracellular matrix; matrix ... See more keywords