Pivotal factors associated with the immunosuppressive tumor microenvironment and melanoma metastasis
Sign Up to like & getrecommendations! Published in 2021 at "Cancer Medicine"
DOI: 10.1002/cam4.3963
Abstract: Considering melanoma is the deadliest malignancy among dermatoma and presently lacks effective therapies, there is an urgent need to investigate the potential mechanisms underlying melanoma metastasis and determine prospective therapeutic targets for precise treatment of… read more here.
Keywords: melanoma; pivotal factors; associated immunosuppressive; factors associated ... See more keywords
Melanoma metastasis to the bladder: A case report
Sign Up to like & getrecommendations! Published in 2022 at "Urology Case Reports"
DOI: 10.1016/j.eucr.2021.101941
Abstract: Metastasis of malignant melanoma to the bladder is rarely seen clinically with only 29 cases reported in English-language literature. However, autopsy series of melanoma patients have shown that metastasis to the bladder could be as… read more here.
Keywords: bladder; metastasis bladder; case; metastasis ... See more keywords
Malignant melanoma metastasis in the gallbladder. A case report of an unusual metastatic site
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Surgery Case Reports"
DOI: 10.1016/j.ijscr.2020.09.116
Abstract: Highlights • Malignant melanoma metastasis into the gallbladder is a rare issue.• Surgical treatment in a metastasized situation has to be carefully evaluated.• Prevention of possible biliary complications is of significant importance. read more here.
Keywords: melanoma metastasis; metastasis gallbladder; malignant melanoma; case ... See more keywords
PHLPP1 mediates melanoma metastasis suppression through repressing AKT2 activation
Sign Up to like & getrecommendations! Published in 2018 at "Oncogene"
DOI: 10.1038/s41388-017-0061-7
Abstract: PI3K/AKT pathway activation is thought to be a driving force in metastatic melanomas. Members of the pleckstrin homology (PH) domain leucine-rich repeat protein Ser/Thr specific phosphatase family (PHLPP1 and PHLPP2) can regulate AKT activation. By… read more here.
Keywords: phlpp1; phlpp1 mediates; metastasis; activation ... See more keywords
A Targeted Quantitative Proteomic Method Revealed a Substantial Reprogramming of Kinome during Melanoma Metastasis
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DOI: 10.1038/s41598-020-59572-5
Abstract: Kinases are involved in numerous critical cell signaling processes, and dysregulation in kinase signaling is implicated in many types of human cancers. In this study, we applied a parallel-reaction monitoring (PRM)-based targeted proteomic method to… read more here.
Keywords: melanoma; melanoma cells; proteomic method; melanoma metastasis ... See more keywords
mGPDH Deficiency leads to melanoma metastasis via induced NRF2
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.16542
Abstract: Oxidative stress critically influences carcinogenesis and the progression of melanoma, and aggressive malignant melanoma activity is due to its high metastatic ability. Some findings in several cancer cell lines have indicated that mGPDH, a component… read more here.
Keywords: melanoma; mgpdh deficiency; induced nrf2; melanoma metastasis ... See more keywords
Gain of chromosome 1q perturbs a competitive endogenous RNA network to promote melanoma metastasis.
Sign Up to like & getrecommendations! Published in 2022 at "Cancer research"
DOI: 10.1158/0008-5472.can-22-0283
Abstract: Somatic copy number alterations (CNA) promote cancer, but the underlying driver genes may not be comprehensively identified if only the functions of the encoded proteins are considered. mRNAs can act as competitive endogenous RNAs (ceRNA)… read more here.
Keywords: metastasis; competitive endogenous; melanoma metastasis; chromosome ... See more keywords
Bioinformatic analysis reveals hub genes and pathways that promote melanoma metastasis
Sign Up to like & getrecommendations! Published in 2020 at "BMC Cancer"
DOI: 10.1186/s12885-020-07372-5
Abstract: Background Melanoma has the highest mortality rate of all skin tumors, and metastases are the major cause of death from it. The molecular mechanism leading to melanoma metastasis is currently unclear. Methods With the goal… read more here.
Keywords: analysis; hub genes; cxcl8 thbs1; metastasis ... See more keywords
Fucosyltransferase 8 as a driver of melanoma metastasis: a new target for melanoma therapy?
Sign Up to like & getrecommendations! Published in 2017 at "Translational cancer research"
DOI: 10.21037/16284
Abstract: Protein glycosylation is a complex post-translational modification process, often affecting protein folding and function, but it has not been well understood due to the lack of effective tools for the study of this process. read more here.
Keywords: fucosyltransferase driver; driver melanoma; new target; melanoma metastasis ... See more keywords
Evaluation of Clinical and Immunohistochemical Factors Relating to Melanoma Metastasis: Potential Roles of Nestin and Fascin in Melanoma
Sign Up to like & getrecommendations! Published in 2022 at "Diagnostics"
DOI: 10.3390/diagnostics12010219
Abstract: For melanoma treatment, an early diagnosis and a complete resection of the primary tumor is essential. In addition, detection of factors that may be related to metastasis is indispensable. A total of 30 Japanese patients… read more here.
Keywords: potential roles; melanoma metastasis; nestin fascin; fascin melanoma ... See more keywords
Identification of key candidate genes involved in melanoma metastasis
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Medicine Reports"
DOI: 10.3892/mmr.2019.10314
Abstract: Metastasis is the most lethal stage of cancer progression. The present study aimed to investigate the underlying molecular mechanisms of melanoma metastasis using bioinformatics. Using the microarray dataset GSE8401 from the Gene Expression Omnibus database,… read more here.
Keywords: analysis; metastasis; melanoma metastasis; key candidate ... See more keywords