Melanoma tumour vasculature heterogeneity: from mice models to human
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cancer Research and Clinical Oncology"
DOI: 10.1007/s00432-018-2809-z
Abstract: Tumour angiogenesis is defined by an anarchic vasculature and irregularities in alignment of endothelial cells. These structural abnormalities could explain the variability in distribution of nanomedicines in various tumour models. Then, the main goal of… read more here.
Keywords: melanoma; vasculature; melanoma models; mice ... See more keywords
Melanoma models for the next generation of therapies.
Sign Up to like & getrecommendations! Published in 2021 at "Cancer cell"
DOI: 10.1016/j.ccell.2021.01.011
Abstract: There is a lack of appropriate melanoma models that can be used to evaluate the efficacy of novel therapeutic modalities. Here, we discuss the current state of the art of melanoma models including genetically engineered… read more here.
Keywords: melanoma; models next; generation therapies; melanoma models ... See more keywords
Abstract LB-A14: ER stress induced by 4-nerolidylcathecol (4-NC) promotes antitumor effects in BRAFi/MEKi sensitive and resistant melanoma models
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Cancer Therapeutics"
DOI: 10.1158/1535-7163.targ-17-lb-a14
Abstract: Melanoma accounts for only 4% of skin malignancies, but it has a high mortality rate. Though the specific inhibitors of MAPK pathway (BRAFi and MEKi) have revolutionized melanoma treatment, most of patients are subject to… read more here.
Keywords: melanoma; resistant melanoma; melanoma models; stress induced ... See more keywords
AGI-134: a fully synthetic α-Gal glycolipid that converts tumors into in situ autologous vaccines, induces anti-tumor immunity and is synergistic with an anti-PD-1 antibody in mouse melanoma models
Sign Up to like & getrecommendations! Published in 2019 at "Cancer Cell International"
DOI: 10.1186/s12935-019-1059-8
Abstract: BackgroundTreatments that generate T cell-mediated immunity to a patient’s unique neoantigens are the current holy grail of cancer immunotherapy. In particular, treatments that do not require cumbersome and individualized ex vivo processing or manufacturing processes… read more here.
Keywords: anti antibody; melanoma models; anti gal; agi 134 ... See more keywords