Genes regulated by DNA methylation are involved in distinct phenotypes during melanoma progression and are prognostic factors for patients
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Oncology"
DOI: 10.1002/1878-0261.13185
Abstract: In addition to mutations, epigenetic alterations are important contributors to malignant transformation and tumor progression. The aim of this work was to identify epigenetic events in which promoter or gene body DNA methylation induces gene… read more here.
Keywords: melanoma progression; progression; dna methylation; gene expression ... See more keywords
MUC21 controls melanoma progression via regulating SLITRK5 and hedgehog signaling pathway
Sign Up to like & getrecommendations! Published in 2022 at "Cell Biology International"
DOI: 10.1002/cbin.11817
Abstract: Mucins are heavily glycosylated proteins secreted by various cell types, to protect the epithelial surface of the gastrointestinal tract from damage. Currently, increasing studies provided evidence to suggest that mucins play an essential role in… read more here.
Keywords: muc21; hedgehog; progression; melanoma progression ... See more keywords
p62/SQSTM1 Fuels Melanoma Progression by Opposing mRNA Decay of a Selective Set of Pro-metastatic Factors.
Sign Up to like & getrecommendations! Published in 2019 at "Cancer cell"
DOI: 10.1016/j.ccell.2018.11.008
Abstract: Modulators of mRNA stability are not well understood in melanoma, an aggressive tumor with complex changes in the transcriptome. Here we report the ability of p62/SQSTM1 to extend mRNA half-life of a spectrum of pro-metastatic… read more here.
Keywords: metastatic factors; p62 sqstm1; sqstm1 fuels; pro metastatic ... See more keywords
PGC1a at the Nexus of Cancer Stem Cell Fates
Sign Up to like & getrecommendations! Published in 2018 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2018.10.391
Abstract: Cancer cells reprogram their metabolism using different strategies to meet anabolic demands to maintain growth and survival. Defining the molecular and genetic determinants of these metabolic programs, including ROS metabolism, is critical to successfully exploit… read more here.
Keywords: ros detoxification; pgc1a; cancer; melanoma progression ... See more keywords
Circ_0062270 upregulates EPHA2 to facilitate melanoma progression via sponging miR-331-3p.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of dermatological science"
DOI: 10.1016/j.jdermsci.2021.08.005
Abstract: BACKGROUND Circular RNA (circRNA) has been confirmed to play a vital role in melanoma progression. OBJECTIVE The regulatory function of circ_0062270, a novel circRNA, in melanoma progression is unclear. METHODS Relative expression levels of circ_0062270… read more here.
Keywords: circ 0062270; melanoma progression; melanoma; mir 331 ... See more keywords
A-to-I miR-378a-3p editing can prevent melanoma progression via regulation of PARVA expression
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-02851-7
Abstract: Previously we have reported that metastatic melanoma cell lines and tumor specimens have reduced expression of ADAR1 and consequently are impaired in their ability to perform A-to-I microRNA (miRNA) editing. The effects of A-to-I miRNAs… read more here.
Keywords: melanoma; melanoma progression; edited form; expression ... See more keywords
The unfolded protein response impacts melanoma progression by enhancing FGF expression and can be antagonized by a chemical chaperone
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-17888-9
Abstract: The mechanisms hallmarking melanoma progression are insufficiently understood. Here we studied the impact of the unfolded protein response (UPR) - a signalling cascade playing ambiguous roles in carcinogenesis - in melanoma malignancy. We identified isogenic… read more here.
Keywords: unfolded protein; protein response; fgf expression; expression ... See more keywords
Non‐invasive metabolic imaging of melanoma progression
Sign Up to like & getrecommendations! Published in 2017 at "Experimental Dermatology"
DOI: 10.1111/exd.13274
Abstract: Skin cancer is associated with abnormal cellular metabolism which if identified early introduces the possibility of intervention to prevent its progress to a deadly metastatic stage. This study combines multiphoton microscopy with fluorescence lifetime imaging… read more here.
Keywords: melanoma; melanoma progression; non invasive; invasive metabolic ... See more keywords
Abstract 1357: Alpha-synuclein may promote melanoma progression by modulating the levels of tetraspanin proteins
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-1357
Abstract: Alpha-synuclein (α-syn; encoded by gene SNCA), which is an intrinsically disordered protein belonging to the synuclein family, is a common biological factor in Parkinson’s disease and melanoma. Aggressive melanomas express high levels of α-syn, but… read more here.
Keywords: melanoma; progression; alpha synuclein; melanoma progression ... See more keywords
Abstract 2536: Intracellular Ctla4 overexpression promotes melanoma progression and metastasis
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-2536
Abstract: Cytotoxic T Lymphocyte Antigen 4 (CTLA4) expressed on the surface of T cells is an important immunotherapeutic target in many cancers, including melanoma. However, we previously found highly upregulated expression of CTLA4 in BRAF/NRAS-mutant human… read more here.
Keywords: progression metastasis; melanoma progression; ctla4; melanoma ... See more keywords
Abstract B07: The loss function of BP180 (Collagen type XVII) in skin, leads to a mast cell dependent pro-inflammatory microenvironment which promotes melanoma progression
Sign Up to like & getrecommendations! Published in 2017 at "Cancer immunology research"
DOI: 10.1158/2326-6074.tumimm16-b07
Abstract: BP180, also known as type 17 collagen, is a transmembrane glycoprotein located in the hemidesmosome of epidermal basal keratinocytes. BP180 is a critical cell/matrix adhesion molecule in dermal-epidermal junction of the skin. Various clinical reports… read more here.
Keywords: skin; bp180; function; melanoma progression ... See more keywords