Enrichment of Melanoma Stem-Like Cells via Sphere Assays.
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DOI: 10.1007/978-1-0716-1205-7_14
Abstract: Sphere assays are widely used in vitro techniques to enrich and evaluate the stem-like cell behavior of both normal and cancer cells. Utilizing three-dimensional in vitro sphere culture conditions provide a better representation of tumor… read more here.
Keywords: like cells; stem like; enrichment melanoma; sphere assays ... See more keywords
Shrimp miR-S8 Suppresses the Stemness of Human Melanoma Stem-like Cells by Targeting the Transcription Factor YB-1.
Sign Up to like & getrecommendations! Published in 2017 at "Cancer research"
DOI: 10.1158/0008-5472.can-17-1375
Abstract: Cross-species regulation of gene expression by microRNA is a possible untapped opportunity for miRNA-based therapy. In this study, we report a novel approach to ablate melanoma stem-like cells by targeting the transcription factor YB-1, which… read more here.
Keywords: stem like; like cells; melanoma stem; cells targeting ... See more keywords
Employing CRISPR-Cas9 to Generate CD133 Synthetic Lethal Melanoma Stem Cells
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23042333
Abstract: Malignant melanoma is a lethal skin cancer containing melanoma-initiating cells (MIC) implicated in tumorigenesis, invasion, and drug resistance, and is characterized by the elevated expression of stem cell markers, including CD133. The siRNA knockdown of… read more here.
Keywords: crispr cas9; melanoma stem; melanoma; cd133 ... See more keywords
Monensin may inhibit melanoma by regulating the selection between differentiation and stemness of melanoma stem cells
Sign Up to like & getrecommendations! Published in 2019 at "PeerJ"
DOI: 10.7717/peerj.7354
Abstract: Melanoma is the most lethal cutaneous malignancy that threatens human lives. Poor sensitivity to chemotherapy drugs and the high rate of resistance are the bottlenecks of melanoma treatment. Thus, new chemotherapy drugs are needed. Drug… read more here.
Keywords: melanoma; differentiation; monensin; stem cells ... See more keywords