AMPK phosphorylates ZDHHC13 to increase MC1R activity and suppress melanomagenesis.
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DOI: 10.1158/0008-5472.can-22-2595
Abstract: Inherited genetic variations in the melanocortin-1 receptor (MC1R) responsible for human red hair color (RHC-variants) are associated with impaired DNA damage repair and increased melanoma risk. MC1R signaling is critically dependent on palmitoylation, primarily mediated… read more here.
Keywords: rhc; phosphorylates zdhhc13; melanomagenesis; mc1r ... See more keywords
Abstract 1149: Targeting Rad6B suppresses melanomagenesis
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DOI: 10.1158/1538-7445.am2017-1149
Abstract: Active β-catenin signaling in melanoma is associated with aggressive disease. We have previously shown that Rad6B, an ubiquitin conjugating enzyme, is a positive regulator of β-catenin stability and transcriptional activity, and is itself a transcriptional… read more here.
Keywords: melanoma; catenin; rad6b; rad6b suppresses ... See more keywords
Role of the Skin Microenvironment in Melanomagenesis: Epidermal Keratinocytes and Dermal Fibroblasts Promote BRAF Oncogene-Induced Senescence Escape in Melanocytes
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DOI: 10.3390/cancers14051233
Abstract: Simple Summary Melanoma is a deadly skin cancer caused by the uncontrolled proliferation of melanocytes, a population of specialized cells that produce the skin pigment melanin. An aberrant proliferation of melanocytes is common, manifesting as… read more here.
Keywords: melanomagenesis; proliferation; escape; skin microenvironment ... See more keywords