Risk Factors Associated With First and Second Primary Melanomas in a High-Incidence Population.
Sign Up to like & getrecommendations! Published in 2022 at "JAMA dermatology"
DOI: 10.1001/jamadermatol.2022.4975
Abstract: Importance An increasing number of people develop more than 1 primary melanoma, yet to date, no population-based prospective cohort studies have reported on risk factors for developing first vs second primary melanomas. Objective To compare… read more here.
Keywords: primary melanoma; first second; second primary; melanoma ... See more keywords
Clinicopathologic and molecular characterization of melanomas mutated for CTNNB1 and MAPK
Sign Up to like & getrecommendations! Published in 2021 at "Virchows Archiv"
DOI: 10.1007/s00428-021-03119-0
Abstract: Wnt/β-catenin signaling plays crucial roles in melanocyte biology and may be implicated in melanoma progression. In this study, we retrospectively examined a real-life cohort of melanomas mutated for β-catenin (CTNNB1), in association or not with… read more here.
Keywords: melanomas; melanomas mutated; clinicopathologic molecular; ctnnb1 mapk ... See more keywords
Melanoma recognition by a deep learning convolutional neural network-Performance in different melanoma subtypes and localisations.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of cancer"
DOI: 10.1016/j.ejca.2019.11.020
Abstract: BACKGROUND Deep learning convolutional neural networks (CNNs) show great potential for melanoma diagnosis. Melanoma thickness at diagnosis among others depends on melanoma localisation and subtype (e.g. advanced thickness in acrolentiginous or nodular melanomas). The question whether… read more here.
Keywords: melanoma; melanomas; deep learning; performance ... See more keywords
Prognostic importance of mitochondrial markers in mucosal and cutaneous head and neck melanomas.
Sign Up to like & getrecommendations! Published in 2019 at "Human pathology"
DOI: 10.1016/j.humpath.2018.11.009
Abstract: Mitochondrial dysfunction is caused by an imbalance in the fission and fusion processes, and it has been implicated in the pathogenesis of several human cancers. However, the role of mitochondrial markers in melanomas still remains… read more here.
Keywords: melanomas; head neck; mitochondrial markers; neck melanomas ... See more keywords
Risk factors for positive or equivocal margins after wide local excision of 1345 cutaneous melanomas
Sign Up to like & getrecommendations! Published in 2017 at "Journal of the American Academy of Dermatology"
DOI: 10.1016/j.jaad.2017.03.025
Abstract: Background Positive or equivocal margins after wide local excision (WLE) complicate surgical management of cutaneous melanoma. Objective To identify the frequency of and risk factors for positive or equivocal margins after WLE of cutaneous melanoma.… read more here.
Keywords: melanomas; positive equivocal; margins wide; risk factors ... See more keywords
Unexpected UVR and non-UVR mutation burden in some acral and cutaneous melanomas
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DOI: 10.1038/labinvest.2016.143
Abstract: Ultraviolet radiation (UVR) mutagenesis causes nearly all cutaneous melanomas, however, since UVR signatures are largely absent in acral melanoma, as well as melanoma in sun-protected sites, the cause of these melanomas is unknown. Whole-genome sequencing… read more here.
Keywords: melanomas; non uvr; mutation burden; cutaneous melanomas ... See more keywords
The Markers Auxiliary in Differential Diagnosis of Early Melanomas and Benign Nevi Sharing Some Similar Features Potentially Leading to Misdiagnosis – A Review of Immunohistochemical Studies
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DOI: 10.1080/07357907.2022.2134415
Abstract: Abstract Although most melanocytic skin lesions are correctly diagnosed, numerous studies have shown interobserver disagreement. This review analyzes 20 molecules as immunohistochemical markers for distinguishing dysplastic and/or Spitz nevi from early melanomas (in situ, Clark… read more here.
Keywords: review; markers auxiliary; early melanomas; spitz nevi ... See more keywords
Increased incidence of melanoma in children and adolescents in Finland in 1990–2014: nationwide re-evaluation of histopathological characteristics
Sign Up to like & getrecommendations! Published in 2022 at "Annals of Medicine"
DOI: 10.1080/07853890.2022.2026001
Abstract: Abstract Background Changes in the incidence of melanoma in children and adolescents have been reported in Europe and in the USA in the recent decades. Aims The aim of this study was to examine the… read more here.
Keywords: finland 1990; melanoma; incidence; 1990 2014 ... See more keywords
Prognostic significance of cyclooxygenase 2 and phosphorylated Akt1 overexpression in primary nonmetastatic and metastatic cutaneous melanomas
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DOI: 10.1097/cmr.0000000000000368
Abstract: Cyclooxygenase 2 (COX-2) and phosphorylated Akt1 (p-Akt1) are associated with tumor spreading, cell proliferation, high metabolism, and angiogenesis in solid tumors. This study aimed to investigate COX-2 and p-Akt1 expression in primary and metastatic melanomas… read more here.
Keywords: melanomas; cyclooxygenase; primary nonmetastatic; cox ... See more keywords
Clinicopathological features and programmed death-ligand 1 immunohistochemical expression in a multicenter cohort of uterine and ovarian melanomas: a retrospective study in Japan (KCOG-G1701s)
Sign Up to like & getrecommendations! Published in 2022 at "Melanoma Research"
DOI: 10.1097/cmr.0000000000000811
Abstract: The objective of this study was to propose prognostic factors and optimal treatment strategies by analyzing the clinicopathological features and programmed death-ligand 1 (PD-L1) expression. We analyzed 31 patients diagnosed with uterine or ovarian melanoma… read more here.
Keywords: uterine ovarian; survival; ovarian melanomas; expression ... See more keywords
Lack of association between anatomical sites of scalp melanomas and brain metastases does not support direct vascular spread
Sign Up to like & getrecommendations! Published in 2022 at "Melanoma Research"
DOI: 10.1097/cmr.0000000000000827
Abstract: Primary scalp melanomas are associated with a higher rate of brain metastasis than primary cutaneous melanomas occurring at other head and neck and body sites, but the reason is unclear. Spread to brain parenchyma via… read more here.
Keywords: brain metastases; brain; scalp melanomas; spread ... See more keywords