Fusion of ALK to the melanophilin gene MLPH in pediatric Spitz nevi.
Sign Up to like & getrecommendations! Published in 2019 at "Human pathology"
DOI: 10.1016/j.humpath.2019.03.002
Abstract: Spitzoid neoplasms typically affect young individuals and include Spitz nevus, atypical Spitz tumor, and Spitzoid melanoma. Spitz tumors can exhibit gene fusions involving the receptor tyrosine kinases NTRK1, NTRK3, ALK, ROS1, RET, or MET, or… read more here.
Keywords: spitz nevi; melanophilin; alk; fusion ... See more keywords
The absence of Rab27a accelerates the degradation of Melanophilin
Sign Up to like & getrecommendations! Published in 2019 at "Experimental Dermatology"
DOI: 10.1111/exd.13840
Abstract: Melanophilin (Mlph) forms an interaction with Rab27a and the actinâbased motor protein MyosinVa (MyoVa) on mature melanosome membranes and the tripartite complex regulates melanosome transport in melanocytes. In this study, we found that Rab27a siRNA… read more here.
Keywords: degradation; melanophilin; rab27a; absence rab27a ... See more keywords