Melatonin binds with high affinity and specificity to beta‐amyloid: LC‐MS provides insight into Alzheimer’s disease treatment
Sign Up to like & getrecommendations! Published in 2021 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.13279
Abstract: To study the potential relationship between melatonin and beta‐amyloid (Abeta), we established a liquid chromatography–mass spectrometry (LC‐MS) method to quantitatively analyze melatonin, deuterated isotopes (melatonin‐D4), and internal standard 6‐iodo‐2‐(4'‐dimethylamino‐) phenyl‐imidazo(1,2) pyridine (IMPY) under positive (+)… read more here.
Keywords: melatonin; alzheimer disease; beta amyloid; affinity ... See more keywords
Melatonin Ameliorates Depressive‐Like Behaviors in Ovariectomized Mice by Improving Tryptophan Metabolism via Inhibition of Gut Microbe Alistipes Inops
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Science"
DOI: 10.1002/advs.202309473
Abstract: Melatonin (N‐acetyl‐5‐methoxytryptamine) is reported to improve mood disorders in perimenopausal women and gut microbiome composition is altered during menopausal period. The possible role of microbiome in the treatment effect of melatonin on menopausal depression remains… read more here.
Keywords: like behaviors; operated mice; alistipes inops; depressive like ... See more keywords
Melatonin Modulates Glucose Metabolism Reprogramming via Targeting G6PD to Alleviate Lead‐Induced Hepatocytes Pyroptosis in Common Carp (Cyprinus carpio L.)
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DOI: 10.1002/advs.202501041
Abstract: Lead (Pb) is a prevalent toxic contaminant that accumulates in freshwater ecosystems, posing severe toxicity to non‐target species such as fish and contributing to the pathogenesis of liver disease. Melatonin (Mel) is a well‐known natural… read more here.
Keywords: mel; glucose metabolism; melatonin; hepatocytes pyroptosis ... See more keywords
Comparative analyses of site‐directed mutagenesis of human melatonin MTNR1A and MTNR1B receptors using a yeast fluorescent biosensor
Sign Up to like & getrecommendations! Published in 2020 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.27609
Abstract: Melatonin is an indoleamine neurohormone made by the pineal gland. Its receptors, MTNR1A and MTNR1B, are members of the G‐protein‐coupled receptor (GPCR) family and are involved in sleep, circadian rhythm, and mood disorders, and in… read more here.
Keywords: mtnr1a mtnr1b; melatonin receptors; biosensor; melatonin ... See more keywords
Improvement of sleep and melatonin in children with autism spectrum disorder after β‐1,3/1,6‐glucan consumption: An open‐label prospective pilot clinical study
Sign Up to like & getrecommendations! Published in 2022 at "Brain and Behavior"
DOI: 10.1002/brb3.2750
Abstract: Poor sleep quality is a major problem in patients with autism spectrum disorder (ASD), and is attributed to low melatonin levels. Melatonin supplementation is recommended; however, its effectiveness varies. β‐Glucans have previously been shown to… read more here.
Keywords: spectrum disorder; autism spectrum; melatonin; pilot ... See more keywords
Melatonin upregulates BMAL1 to attenuate chronic sleep deprivation‐related cognitive impairment by alleviating oxidative stress
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DOI: 10.1002/brb3.2836
Abstract: To investigate the mechanism underlying the regulatory effect of melatonin on chronic sleep deprivation‐related cognitive impairment. read more here.
Keywords: deprivation related; chronic sleep; sleep deprivation; cognitive impairment ... See more keywords
Melatonin promotes neuroblastoma cell differentiation by activating hyaluronan synthase 3‐induced mitophagy
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DOI: 10.1002/cam4.2389
Abstract: Neuroblastoma is the second most common pediatric malignancy and has a high rate of spontaneous remission. Uncovering the mechanisms underlying neuroblastoma cell differentiation is critical for therapeutic purposes. A neuroblastoma cell line (N2a) treated with… read more here.
Keywords: hyaluronan synthase; cell differentiation; differentiation; neuroblastoma cell ... See more keywords
Melatonin protects H9c2 cardiomyoblasts from oxygen‐glucose deprivation and reperfusion‐induced injury by inhibiting Rac1/JNK/Foxo3a/Bim signaling pathway
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DOI: 10.1002/cbin.11739
Abstract: Melatonin has been shown to protect against ischemia/reperfusion (I/R)‐induced myocardial injury, however, the precise molecular mechanisms have not been fully clarified. The present study was aimed to investigate whether inactivation of Rac1/JNK/Foxo3a/Bim signaling pathway is… read more here.
Keywords: injury; melatonin; signaling pathway; foxo3a bim ... See more keywords
Temporal effect of melatonin posttreatment on anoxia/reoxygenation injury in H9c2 cells
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DOI: 10.1002/cbin.11759
Abstract: Melatonin has been proven to reduce myocardial ischemia‐reperfusion (MI/R) injury. However, in most studies, melatonin was administered before MI/R, thus, the results lack clinical significance in patients with acute myocardial infarction. We hypothesize that melatonin… read more here.
Keywords: reoxygenation; h9c2 cells; melatonin posttreatment; injury ... See more keywords
A Survey of Melatonin in Dietary Supplement Products Sold in the United States.
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DOI: 10.1002/dta.3823
Abstract: In the United States, melatonin products are widely available as dietary supplements. During the past few decades, melatonin products have gained popularity primarily as a sleep aid, with a variety of product forms available for… read more here.
Keywords: united states; product; supplement products; dietary supplement ... See more keywords
Influence of melatonin on the successful infection of Daphnia dentifera by Metschnikowia bicuspidata
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DOI: 10.1002/ecs2.70192
Abstract: The levels of the hormone melatonin fluctuate daily, with higher concentrations often found at night. These fluctuations likely influence multiple aspects of physiology, including the immune response. We demonstrated that the addition of exogenous melatonin… read more here.
Keywords: host; metschnikowia; daphnia dentifera; exogenous melatonin ... See more keywords