Melatonin binds with high affinity and specificity to beta‐amyloid: LC‐MS provides insight into Alzheimer’s disease treatment
Sign Up to like & getrecommendations! Published in 2021 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.13279
Abstract: To study the potential relationship between melatonin and beta‐amyloid (Abeta), we established a liquid chromatography–mass spectrometry (LC‐MS) method to quantitatively analyze melatonin, deuterated isotopes (melatonin‐D4), and internal standard 6‐iodo‐2‐(4'‐dimethylamino‐) phenyl‐imidazo(1,2) pyridine (IMPY) under positive (+)… read more here.
Keywords: melatonin; alzheimer disease; beta amyloid; affinity ... See more keywords
Comparative analyses of site‐directed mutagenesis of human melatonin MTNR1A and MTNR1B receptors using a yeast fluorescent biosensor
Sign Up to like & getrecommendations! Published in 2020 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.27609
Abstract: Melatonin is an indoleamine neurohormone made by the pineal gland. Its receptors, MTNR1A and MTNR1B, are members of the G‐protein‐coupled receptor (GPCR) family and are involved in sleep, circadian rhythm, and mood disorders, and in… read more here.
Keywords: mtnr1a mtnr1b; melatonin receptors; biosensor; melatonin ... See more keywords
Improvement of sleep and melatonin in children with autism spectrum disorder after β‐1,3/1,6‐glucan consumption: An open‐label prospective pilot clinical study
Sign Up to like & getrecommendations! Published in 2022 at "Brain and Behavior"
DOI: 10.1002/brb3.2750
Abstract: Poor sleep quality is a major problem in patients with autism spectrum disorder (ASD), and is attributed to low melatonin levels. Melatonin supplementation is recommended; however, its effectiveness varies. β‐Glucans have previously been shown to… read more here.
Keywords: spectrum disorder; autism spectrum; melatonin; pilot ... See more keywords
Melatonin upregulates BMAL1 to attenuate chronic sleep deprivation‐related cognitive impairment by alleviating oxidative stress
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DOI: 10.1002/brb3.2836
Abstract: To investigate the mechanism underlying the regulatory effect of melatonin on chronic sleep deprivation‐related cognitive impairment. read more here.
Keywords: deprivation related; chronic sleep; sleep deprivation; cognitive impairment ... See more keywords
Melatonin promotes neuroblastoma cell differentiation by activating hyaluronan synthase 3‐induced mitophagy
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DOI: 10.1002/cam4.2389
Abstract: Neuroblastoma is the second most common pediatric malignancy and has a high rate of spontaneous remission. Uncovering the mechanisms underlying neuroblastoma cell differentiation is critical for therapeutic purposes. A neuroblastoma cell line (N2a) treated with… read more here.
Keywords: hyaluronan synthase; cell differentiation; differentiation; neuroblastoma cell ... See more keywords
Melatonin protects H9c2 cardiomyoblasts from oxygen‐glucose deprivation and reperfusion‐induced injury by inhibiting Rac1/JNK/Foxo3a/Bim signaling pathway
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DOI: 10.1002/cbin.11739
Abstract: Melatonin has been shown to protect against ischemia/reperfusion (I/R)‐induced myocardial injury, however, the precise molecular mechanisms have not been fully clarified. The present study was aimed to investigate whether inactivation of Rac1/JNK/Foxo3a/Bim signaling pathway is… read more here.
Keywords: injury; melatonin; signaling pathway; foxo3a bim ... See more keywords
Temporal effect of melatonin posttreatment on anoxia/reoxygenation injury in H9c2 cells
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DOI: 10.1002/cbin.11759
Abstract: Melatonin has been proven to reduce myocardial ischemia‐reperfusion (MI/R) injury. However, in most studies, melatonin was administered before MI/R, thus, the results lack clinical significance in patients with acute myocardial infarction. We hypothesize that melatonin… read more here.
Keywords: reoxygenation; h9c2 cells; melatonin posttreatment; injury ... See more keywords
Impact of melatonin receptor‐signaling on Zeitgeber time‐dependent changes in cell proliferation and apoptosis in the adult murine hippocampus
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DOI: 10.1002/hipo.22706
Abstract: The hippocampus is subjected to diurnal/circadian rhythms on both the morphological and molecular levels. Certain aspects of cell proliferation in the adult hippocampus are regulated by melatonin and accompanied by apoptosis to ensure proper tissue… read more here.
Keywords: hippocampus; apoptosis; dependent changes; cell proliferation ... See more keywords
Human hepatocellular carcinoma: Protection by melatonin
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DOI: 10.1002/jcp.26586
Abstract: Despite great scientific breakthroughs toward understanding the identity of human hepatocellular carcinoma (HCC) mechanistically, there are still no clinically efficient therapeutic methods for this cancer. Melatonin (N‐acetyl‐5‐methoxytryptamine) is a multi‐tasking hormone that has long been… read more here.
Keywords: hepatocellular carcinoma; hcc; cancer; melatonin ... See more keywords
Adjuvant chemotherapy with melatonin for targeting human cancers: A review
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DOI: 10.1002/jcp.27259
Abstract: Melatonin is a multifunctional hormone that has long been known for its antitumoral effects. An advantage of the application of melatonin in cancer therapy is its ability to differentially influence tumors from normal cells. In… read more here.
Keywords: chemotherapy; combination; therapy; human cancers ... See more keywords
Immunoregulatory role of melatonin in cancer
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DOI: 10.1002/jcp.29036
Abstract: Melatonin is a ubiquitous indole amine that plays a fundamental role in the regulation of the biological rhythm. Disrupted circadian rhythm alters the expression of clock genes and deregulates oncogenes, which finally promote tumor development… read more here.
Keywords: role melatonin; immune cell; role; melatonin ... See more keywords