The melatonin-MT1 receptor axis modulates tumor growth in PTEN-mutated gliomas.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.02.010
Abstract: More than 40% of glioma patients have tumors that harbor PTEN (phosphatase and tensin homologue deleted on chromosome ten) mutations; this disease is associated with poor therapeutic resistance and outcome. Such mutations are linked to… read more here.
Keywords: glioma; melatonin mt1; melatonin; growth ... See more keywords
Sleep well. Untangling the role of melatonin MT1 and MT2 receptors in sleep
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Pineal Research"
DOI: 10.1111/jpi.12544
Abstract: The pharmacological potential of targeting selectively melatonin MT1 or MT2 receptors has not yet been exploited in medicine. Research using selective MT1/MT2 receptor ligands and MT1/MT2 receptor knockout mice has indicated that the activation of… read more here.
Keywords: melatonin mt1; mt1 mt2; mt2; mt2 receptors ... See more keywords
Melatonin MT1 and MT2 receptor ERK signaling is differentially dependent on Gi/o and Gq/11 proteins
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Pineal Research"
DOI: 10.1111/jpi.12641
Abstract: G protein‐coupled receptors (GPCRs) transmit extracellular signals into cells by activating G protein‐ and β‐arrestin‐dependent pathways. Extracellular signal‐regulated kinases (ERKs) play a central role in integrating these different linear inputs coming from a variety of… read more here.
Keywords: mt1 mt2; mt2; erk; melatonin mt1 ... See more keywords