Knockdown of melatonin receptor 1 and induction of follicle-stimulating hormone on the regulation of mouse granulosa cell function.
Sign Up to like & getrecommendations! Published in 2017 at "Reproductive biology"
DOI: 10.1016/j.repbio.2017.10.005
Abstract: Melatonin receptor 1 (MT1) performs a critical role in the regulation of the animal reproductive system, particularly in follicular growth, and has a considerable effect on reproductive performance. However, the role that MT1 plays in… read more here.
Keywords: follicle stimulating; cell; mt1; function ... See more keywords
Discovery of a Potent and Orally Bioavailable Melatonin Receptor Agonist.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.0c01836
Abstract: To develop potent and orally bioavailable melatonin receptor (MT1 and MT2) agonists, a novel series of 5-6-5 tricyclic derivatives was designed, synthesized, and evaluated. The synthesized indeno[5,4-d][1,3]oxazole, cyclopenta[c]pyrazolo[1,5-a]pyridine, indeno[5,4-d][1,3]thiazole, and cyclopenta[e]indazole derivatives showed potent binding… read more here.
Keywords: potent orally; orally bioavailable; bioavailable melatonin; melatonin receptor ... See more keywords
Tetrahydroquinoline Ring as a Versatile Bioisostere of Tetralin for Melatonin Receptor Ligands.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.8b00359
Abstract: A new family of melatonin receptor ligands, characterized by a tetrahydroquinoline (THQ) scaffold carrying an amide chain in position 3, was devised as conformationally constrained analogs of flexible N-anilinoethylamides previously developed. Molecular superposition models allowed… read more here.
Keywords: tetrahydroquinoline ring; ring versatile; receptor ligands; receptor ... See more keywords
Melatonergic systems of AANAT, melatonin, and its receptor MT2 in the corpus luteum are essential for reproductive success in mammals†
Sign Up to like & getrecommendations! Published in 2020 at "Biology of Reproduction"
DOI: 10.1093/biolre/ioaa190
Abstract: Abstract Corpus luteum (CL) plays a critical role in mammalian reproductive physiology. Its dysfunction will lead to infertility or habitual abortion. In the current study, by use of melatonin specific membrane receptor 2 (MT2) knocking… read more here.
Keywords: essential reproductive; reproductive success; aanat melatonin; receptor ... See more keywords
Melatonin receptor type 1A gene linked to Alzheimer’s disease in old age
Sign Up to like & getrecommendations! Published in 2018 at "Sleep"
DOI: 10.1093/sleep/zsy103
Abstract: Abstract Disruption of the circadian rhythms is a frequent preclinical and clinical manifestation of Alzheimer’s disease. Furthermore, it has been suggested that shift work is a risk factor for Alzheimer’s disease. Previously, we have reported… read more here.
Keywords: type gene; alzheimer disease; disease; receptor type ... See more keywords
Melatonin for the treatment of gastroesophageal reflux disease; protocol for a systematic review and meta-analysis
Sign Up to like & getrecommendations! Published in 2019 at "Medicine"
DOI: 10.1097/md.0000000000014241
Abstract: Background: Melatonin generated in the gastrointestinal tract has mucosal protective effect with inhibiting gastric acid secretion, while increasing gastrin release, which in turn stimulates the contractility of lower esophageal sphincter. Gastroesophageal reflux disease (GERD) is… read more here.
Keywords: melatonin; melatonin melatonin; treatment; melatonin receptor ... See more keywords
Melatonin receptor structures shed new light on melatonin research
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Pineal Research"
DOI: 10.1111/jpi.12606
Abstract: The tryptophan derivative melatonin is an evolutionary old molecule that is involved in a pleiotropy of physiological functions. In humans, age‐related decline of circulating melatonin levels and/or dysregulation of its circadian synthesis pattern have been… read more here.
Keywords: research melatonin; research; receptor structures; structures shed ... See more keywords
Activation of melatonin receptor 1 by CRISPR‐Cas9 activator ameliorates cognitive deficits in an Alzheimer's disease mouse model
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Pineal Research"
DOI: 10.1111/jpi.12787
Abstract: Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by the presence of neurotoxic beta‐amyloid (Aβ) in the brain. Melatonin receptors have been reported to associate with aging and AD, and their expression decreased with… read more here.
Keywords: cas9 activator; activation; melatonin; melatonin receptor ... See more keywords
Melatonin receptor agonist ramelteon alleviates experimental acute ocular inflammation via HIF-1Α/VEGF/E-NOS signaling
Sign Up to like & getrecommendations! Published in 2022 at "European Journal of Ophthalmology"
DOI: 10.1177/11206721221123878
Abstract: Purpose Ramelteon (RML) is a potent, selective agonist of the high-affinity melatonin receptor 1 and 2 receptors. In addition, RML is known to have antioxidant and anti-inflammatory effects. In this study, we aimed to investigate… read more here.
Keywords: melatonin receptor; rml; vegf nos; group ... See more keywords
Protective effects of melatonin receptor agonists on endotoxin-induced uveitis in rats
Sign Up to like & getrecommendations! Published in 2023 at "Iranian Journal of Basic Medical Sciences"
DOI: 10.22038/ijbms.2023.67297.14749
Abstract: Objective(s): Melatonin has an important role in regulating a variety of physiological functions of the body. We investigated the protective effects of Agomelatine (AGO) and Ramelteon (RAME) on Endotoxin-Induced Uveitis (EIU) in rats. Materials and… read more here.
Keywords: melatonin receptor; receptor agonists; group; lps plus ... See more keywords
Long-term environmental exposure of darkness induces hyperandrogenism in PCOS via melatonin receptor 1A and aromatase reduction
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.954186
Abstract: Polycystic ovary syndrome (PCOS) is a common and complex disorder impairing female fertility, yet its etiology remains elusive. It is reported that circadian rhythm disruption might play a crucial role in PCOS pathologic progression. Here,… read more here.
Keywords: melatonin receptor; darkness; pcos; hyperandrogenism ... See more keywords