Comparative analyses of site‐directed mutagenesis of human melatonin MTNR1A and MTNR1B receptors using a yeast fluorescent biosensor
Sign Up to like & getrecommendations! Published in 2020 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.27609
Abstract: Melatonin is an indoleamine neurohormone made by the pineal gland. Its receptors, MTNR1A and MTNR1B, are members of the G‐protein‐coupled receptor (GPCR) family and are involved in sleep, circadian rhythm, and mood disorders, and in… read more here.
Keywords: mtnr1a mtnr1b; melatonin receptors; biosensor; melatonin ... See more keywords
Localization of melatonin and its receptors (melatonin 1a and 1b receptors) in the mouse inner ear
Sign Up to like & getrecommendations! Published in 2019 at "Acta Oto-Laryngologica"
DOI: 10.1080/00016489.2019.1655587
Abstract: Abstract Background: In the inner ear, evidence has been gathered indicating that melatonin plays important roles in inner ear physiology and pathophysiology. However, no attempt has been made previously to investigate the localization or expression… read more here.
Keywords: melatonin receptors; inner ear; mouse inner; localization ... See more keywords
Design and Validation of the First Family of Photo-Activatable Ligands for Melatonin Receptors
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medicinal Chemistry"
DOI: 10.1101/2022.05.05.490738
Abstract: Melatonin is a neurohormone released in a circadian manner with peak levels during the night. In mammals, melatonin mediates its effects mainly through G protein-coupled MT1 and MT2 receptors. Drugs acting on melatonin receptors are… read more here.
Keywords: family; design validation; mcs 0382; validation first ... See more keywords
Combined targeting of fatty acid amide hydrolase and melatonin receptors promotes neuroprotection and stimulates inflammation resolution in rats
Sign Up to like & getrecommendations! Published in 2022 at "British Journal of Pharmacology"
DOI: 10.1111/bph.16014
Abstract: Devising novel strategies to therapeutically favour inflammation resolution and provide neuroprotection is an unmet clinical need. Enhancing endocannabinoid tone by inhibiting the catabolic enzyme fatty acid amide hydrolase (FAAH), or stimulating melatonin receptors has therapeutic… read more here.
Keywords: amide hydrolase; inflammation resolution; acid amide; melatonin receptors ... See more keywords
MT1 and MT2 melatonin receptors are expressed in nonoverlapping neuronal populations
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Pineal Research"
DOI: 10.1111/jpi.12575
Abstract: Melatonin (MLT) exerts its physiological effects principally through two high‐affinity membrane receptors MT1 and MT2. Understanding the exact mechanism of MLT action necessitates the use of highly selective agonists/antagonists to stimulate/inhibit a given MLT receptor.… read more here.
Keywords: mt2 melatonin; mt1 mt2; mt2; melatonin receptors ... See more keywords
The extent of involvement of ouabain, hippocampal expression of Na+/K+-ATPase, and corticosterone/melatonin receptors ratio in modifying stress-induced behavior differs according to the stressor in context
Sign Up to like & getrecommendations! Published in 2022 at "Brazilian Journal of Medical and Biological Research"
DOI: 10.1590/1414-431x2022e11938
Abstract: The aim of this study was to assess the effect of two types of stressors, regarding the extent of involvement of ouabain (OUA), hippocampal sodium/potassium ATPase (NKA) expression, and the hippocampal corticosterone receptors (CR)/melatonin receptors… read more here.
Keywords: stress; involvement ouabain; extent involvement; expression ... See more keywords
Shumian Capsule Improves the Sleep Disorder and Mental Symptoms Through Melatonin Receptors in Sleep-Deprived Mice
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.925828
Abstract: Healthy sleep is vital to maintaining the body's homeostasis. With the development of modern society, sleep disorder has gradually become one of the most epidemic health problems worldwide. Shumian capsule (SMC), a kind of traditional… read more here.
Keywords: sleep disorder; pharmacology; deprived mice; sleep deprived ... See more keywords
Circadian Clock Proteins and Melatonin Receptors in Neurons and Glia of the Sapajus apella Cerebellum
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2018.00005
Abstract: Oscillations of brain proteins in circadian rhythms are important for determining several cellular and physiological processes in anticipation of daily and seasonal environmental rhythms. In addition to the suprachiasmatic nucleus, the primary central oscillator, the… read more here.
Keywords: melatonin receptors; rhythms; expression; cerebellum ... See more keywords
Bos taurus and Cervus elaphus as Non-Seasonal/Seasonal Models for the Role of Melatonin Receptors in the Spermatozoon
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23116284
Abstract: Melatonin is crucial in reproduction due its antioxidant, hormonal, and paracrine action. Melatonin membrane receptors (MT1/MT2) have been confirmed on spermatozoa from several species, but functionality studies are scarce. To clarify their role in ruminants… read more here.
Keywords: role; bos taurus; cervus elaphus; melatonin receptors ... See more keywords
Melatonin Receptors: A Key Mediator in Animal Reproduction
Sign Up to like & getrecommendations! Published in 2022 at "Veterinary Sciences"
DOI: 10.3390/vetsci9070309
Abstract: Simple Summary Animal reproduction is closely related to economic benefits and food safety in domestic animals, as well as human fertility. There are many factors that affect the reproductive ability of animals, among which studies… read more here.
Keywords: melatonin receptors; function; reproduction melatonin; animal reproduction ... See more keywords