Effect of dimerized melittin on gastric cancer cells and antibacterial activity
Sign Up to like & getrecommendations! Published in 2018 at "Amino Acids"
DOI: 10.1007/s00726-018-2587-6
Abstract: Melittin is the peptide toxin found in bee venom and is effective against cancer cells. To enhance its activity, a branched dimeric form of melittin was designed. The monomeric form of the peptide was more… read more here.
Keywords: gastric cancer; melittin; effect; cancer cells ... See more keywords
Apoptotic Effect of Melittin Purified from Iranian Honey Bee Venom on Human Cervical Cancer HeLa Cell Line
Sign Up to like & getrecommendations! Published in 2017 at "International Journal of Peptide Research and Therapeutics"
DOI: 10.1007/s10989-017-9641-1
Abstract: Melittin, an amphipathic 26-residue peptide, is the main component of honey bee venom. Studies have been demonstrated that melittin has an inhibitory effect on proliferation of cancer cells. However, the precise mechanism of action is… read more here.
Keywords: cancer; melittin; honey bee; venom ... See more keywords
Hydrogen-Deuterium Exchange and Electron Capture Dissociation to Interrogate the Conformation of Gaseous Melittin Ions
Sign Up to like & getrecommendations! Published in 2019 at "Journal of The American Society for Mass Spectrometry"
DOI: 10.1007/s13361-019-02150-5
Abstract: AbstractThere is a need in the field of biological mass spectrometry for structural tools which can report on regional, rather than solely global, structure of gaseous protein ions. Site-specific hydrogen-deuterium (H/D) exchange has shown promise… read more here.
Keywords: capture dissociation; electron capture; exchange electron; melittin ... See more keywords
Antiulcerogenic effect of melittin via mitigating TLR4/TRAF6 mediated NF-κB and p38MAPK pathways in acetic acid-induced ulcerative colitis in mice.
Sign Up to like & getrecommendations! Published in 2020 at "Chemico-biological interactions"
DOI: 10.1016/j.cbi.2020.109276
Abstract: Ulcerative colitis (UC) is a chronic disease driven primarily by uncontrolled pervasive inflammatory responses affecting the colon and rectum. Currently available medications carry multiple detrimental adverse effects, which have emphasized the mandatory need for safer… read more here.
Keywords: acid induced; acetic acid; melittin; ulcerative colitis ... See more keywords
Anti-fibrotic effect of melittin on TRIM47 expression in human embryonic lung fibroblast through regulating TRIM47 pathway.
Sign Up to like & getrecommendations! Published in 2020 at "Life sciences"
DOI: 10.1016/j.lfs.2020.117893
Abstract: AIMS To investigate the effect and underlying mechanism of melittin and tripartite motif (TRIM) family in human embryonic lung fibroblast (HELF). MATERIALS AND METHODS Lentiviral RNA interference vector and lentiviral overexpression vector were constructed and… read more here.
Keywords: phosphorylation smad2; melittin; effect; trim47 ... See more keywords
Influence of apitoxin and melittin from Apis mellifera bee on Staphylococcus aureus strains.
Sign Up to like & getrecommendations! Published in 2020 at "Microbial pathogenesis"
DOI: 10.1016/j.micpath.2020.104011
Abstract: The antibacterial activities of apitoxin, a venom produced by Apis mellifera bee, and melittin, an antimicrobial peptide from apitoxin, were tested against planktonic and biofilm states of Staphylococcus aureus methicillin-resistant (MRSA), including clinical, and enterotoxin-producing… read more here.
Keywords: staphylococcus aureus; apis mellifera; apitoxin melittin; melittin ... See more keywords
Solution NMR Structure and Backbone Dynamics of Recombinant Bee Venom Melittin
Sign Up to like & getrecommendations! Published in 2018 at "Biochemistry"
DOI: 10.1021/acs.biochem.8b00156
Abstract: In recent years there has been a resurgence of interest in melittin and its variants as their therapeutic potential has become increasingly evident. Melittin is a 26-residue peptide and a toxic component of honey bee… read more here.
Keywords: solution; melittin; nmr; bee venom ... See more keywords
Modulation of Membrane-Disruptive Activity of Melittin via N- and C-Terminal PEGylation Strategies.
Sign Up to like & getrecommendations! Published in 2025 at "Bioconjugate chemistry"
DOI: 10.1021/acs.bioconjchem.5c00123
Abstract: Melittin has emerged as a promising therapeutic agent due to its potent antitumor and antimicrobial activities. However, the clinical translation of native Melittin is hindered by substantial challenges, including systemic toxicity and rapid proteolytic degradation,… read more here.
Keywords: terminal pegylation; melittin; modulation membrane; activity melittin ... See more keywords
How do the properties of amphiphilic polymer membranes influence the functional insertion of peptide pores?
Sign Up to like & getrecommendations! Published in 2019 at "Biomacromolecules"
DOI: 10.1021/acs.biomac.9b01416
Abstract: Pore-forming peptides are of high biological relevance particularly as cytotoxic agents, but their properties are also applicable for the permeabilization of lipid membranes for biotechnological applications, which can then be translated to the more stable… read more here.
Keywords: functional insertion; peptide; insertion; melittin ... See more keywords
Expression of Melittin in Fusion with GST in Escherichia coli and Its Purification as a Pure Peptide with Good Bacteriostatic Efficacy
Sign Up to like & getrecommendations! Published in 2020 at "ACS Omega"
DOI: 10.1021/acsomega.0c00085
Abstract: The expression and purification of melittin (MET) in microbials are difficult because of its antibacterial activities. In this work, MET was fused with a glutathione-S-transferase (GST) tag and expressed in Escherichia coli to overcome its… read more here.
Keywords: escherichia coli; melittin; gst; expression ... See more keywords
Noncovalent Conjugates of Ionic Liquid with Antibacterial Peptide Melittin: An Efficient Combination against Bacterial Cells
Sign Up to like & getrecommendations! Published in 2020 at "ACS Omega"
DOI: 10.1021/acsomega.9b03777
Abstract: Growing antibiotic resistance has become a major health problem and has encouraged many researchers to find an alternative class of antibiotics. Combination therapy (covalent/noncovalent) is supposed to increase antibacterial activity leading to a decrease in… read more here.
Keywords: combination; ionic liquid; peptide; melittin ... See more keywords