Stereocontrolled Synthesis of (±)-Melokhanine E via an Intramolecular Formal [3 + 2] Cycloaddition.
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DOI: 10.1021/acs.orglett.9b04546
Abstract: A convergent sequence to access the indole alkaloid (±)-melokhanine E in 12-steps (8-step longest linear sequence) and an 11% overall yield is reported. The approach utilizes two cyclopropane moieties as reactive precursors to a 1,3-dipole… read more here.
Keywords: synthesis melokhanine; formal cycloaddition; melokhanine; melokhanine via ... See more keywords