A Phase 3, Randomized, Placebo‐Controlled Evaluation of the Safety of Intravenous Meloxicam Following Major Surgery
Sign Up to like & getrecommendations! Published in 2019 at "Clinical Pharmacology in Drug Development"
DOI: 10.1002/cpdd.666
Abstract: An intravenous (IV) formulation of meloxicam is being studied for moderate to severe pain management. This phase 3, randomized, multicenter, double‐blind, placebo‐controlled trial evaluated the safety of once‐daily meloxicam IV 30 mg in subjects following… read more here.
Keywords: surgery; meloxicam; safety; following major ... See more keywords
A Randomized Double‐Blind Controlled Trial of Intravenous Meloxicam in the Treatment of Pain Following Dental Impaction Surgery
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Pharmacology"
DOI: 10.1002/jcph.1058
Abstract: This randomized, controlled phase 2 study was conducted to evaluate the analgesic efficacy, safety, and tolerability of single intravenous (IV) doses of 15 mg, 30 mg, and 60 mg meloxicam compared with oral ibuprofen 400… read more here.
Keywords: impaction surgery; treatment; meloxicam; dental impaction ... See more keywords
Meloxicam inhibits biofilm formation and enhances antimicrobial agents efficacy by Pseudomonas aeruginosa
Sign Up to like & getrecommendations! Published in 2018 at "MicrobiologyOpen"
DOI: 10.1002/mbo3.545
Abstract: Microbial biofilms are communities of surface‐adhered cells enclosed in a matrix of extracellular polymeric substances. Bacterial cells in biofilm are 10~1,000‐fold more resistant to antimicrobials than the planktonic cells. Burgeoning antibiotic resistance in Pseudomonas aeruginosa… read more here.
Keywords: pseudomonas aeruginosa; antimicrobial agents; meloxicam; biofilm formation ... See more keywords
Intermolecular interaction as a direct measure of water solubility advantage of meloxicam cocrystalized with carboxylic acids
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Molecular Modeling"
DOI: 10.1007/s00894-018-3649-0
Abstract: AbstractThe solubility advantage (SA) of meloxicam cocrystalized with mono- and dicarboxylic acids was expressed in terms of equilibrium constants involving active pharmaceutical ingredient and coformer in aqueous solutions. It is argued that SA can be… read more here.
Keywords: solubility advantage; advantage meloxicam; meloxicam cocrystalized; water ... See more keywords
Effect of levofloxacin, pazufloxacin, enrofloxacin, and meloxicam on the immunolocalization of ABCG-2 transporter protein in rabbit retina
Sign Up to like & getrecommendations! Published in 2018 at "Environmental Science and Pollution Research"
DOI: 10.1007/s11356-018-1216-y
Abstract: Adenosine triphosphate-binding cassette (ABC) sub-family G member-2 (ABCG-2) is a transporter protein, implicated for multi-drug efflux from tissues. This study evaluated the effect of fluoroquinolones; levofloxacin, pazufloxacin and enrofloxacin, and non-steroidal anti-inflammatory drug, meloxicam; on… read more here.
Keywords: alone treated; meloxicam; group; abcg transporter ... See more keywords
Forced and long-term degradation assays of tenoxicam, piroxicam and meloxicam in river water. Degradation products and adsorption to sediment.
Sign Up to like & getrecommendations! Published in 2018 at "Chemosphere"
DOI: 10.1016/j.chemosphere.2017.10.056
Abstract: The fate of the pharmaceutical drugs tenoxicam, piroxicam and meloxicam in river water is evaluated here for first time. So, biological, photochemical and thermal degradation assays have been conducted to estimate their degradation rates and… read more here.
Keywords: degradation; water; meloxicam; piroxicam meloxicam ... See more keywords
Oral Administration of Meloxicam Suppresses Low-Dose Endotoxin Challenge-Induced Pain in Thoroughbred Horses.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of equine veterinary science"
DOI: 10.1016/j.jevs.2019.03.001
Abstract: Nonsteroidal anti-inflammatory drugs such as flunixin meglumine have been used to treat signs of systemic inflammatory conditions, but it is also known to have the side effect to small intestine mucosa. It may be considered… read more here.
Keywords: pain; meloxicam; thoroughbred horses; dose endotoxin ... See more keywords
Physicochemical characterization, the Hirshfeld surface, and biological evaluation of two meloxicam compounding pharmacy samples
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Pharmaceutical Analysis"
DOI: 10.1016/j.jpha.2017.12.006
Abstract: Meloxicam (MLX) is an anti-inflammatory drug susceptible to variations and crystalline transitions. In compounding pharmacies, the complete crystallographic evaluation of the raw material is not a routine procedure. We performed a complete crystallographic characterization of… read more here.
Keywords: hirshfeld surface; compounding pharmacies; meloxicam; pharmacy ... See more keywords
Development and validation of ultra-performance liquid chromatography method for the determination of meloxicam and its impurities in active pharmaceutical ingredients.
Sign Up to like & getrecommendations! Published in 2018 at "Annales pharmaceutiques francaises"
DOI: 10.1016/j.pharma.2018.02.001
Abstract: The main objective was to develop a suitable and rapid ultra-performance liquid chromatography (UPLC) method for the quantitative determination of meloxicam and its impurities. Starting from data in literature, we calculated the new parameters to… read more here.
Keywords: meloxicam impurities; meloxicam; method; liquid chromatography ... See more keywords
Mitigation of electroencephalographic and cardiovascular responses to castration in Bos indicus bulls following the administration of either lidocaine or meloxicam.
Sign Up to like & getrecommendations! Published in 2017 at "Veterinary anaesthesia and analgesia"
DOI: 10.1016/j.vaa.2017.04.009
Abstract: OBJECTIVE To investigate the mitigating effects of administration of local anaesthetic or systemic meloxicam on the electroencephalographic (EEG) and cardiovascular responses during surgical castration of Bos indicus bull calves. STUDY DESIGN Prospective, randomized, experimental study.… read more here.
Keywords: administration; bos indicus; castration bos; meloxicam ... See more keywords
NSAID treatment with meloxicam enhances peripheral stem cell mobilization in myeloma
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DOI: 10.1038/bmt.2017.234
Abstract: Chemotherapy with G–CSF is used to mobilize peripheral stem cells in multiple myeloma (MM) patients, with plerixafor as a rescue strategy for poorly mobilizing patients. Preclinical studies suggested that the nonsteroidal anti-inflammatory drug meloxicam enhances… read more here.
Keywords: cd34; meloxicam enhances; meloxicam; mobilization ... See more keywords