Melphalan induced germ cell toxicity and dose-dependent effects of β-aminoisobutyric acid in experimental rat model: Role of oxidative stress, inflammation and apoptosis.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of biochemical and molecular toxicology"
DOI: 10.1002/jbt.23374
Abstract: The success of chemotherapy regimens has led to an increase in cancer survival rate over the last decades. Melphalan has been widely used for the treatment of several types of cancers despite its gonadotoxic effects.… read more here.
Keywords: germ cell; toxicity; melphalan induced; melphalan ... See more keywords
Prospective Clinical and Pharmacological Evaluation of the Delcath System’s Second-Generation (GEN2) Hemofiltration System in Patients Undergoing Percutaneous Hepatic Perfusion with Melphalan
Sign Up to like & getrecommendations! Published in 2017 at "Cardiovascular and Interventional Radiology"
DOI: 10.1007/s00270-017-1630-4
Abstract: IntroductionPercutaneous hepatic perfusion (PHP) with melphalan is an effective treatment for patients with hepatic metastases, but associated with high rates of bone marrow depression. To reduce systemic toxicity, improvements have been made to the filtration… read more here.
Keywords: system; hepatic perfusion; melphalan; gen2 ... See more keywords
Erratum to: Prospective Clinical and Pharmacological Evaluation of the Delcath System’s Second-Generation (GEN2) Hemofiltration System in Patients Undergoing Percutaneous Hepatic Perfusion with Melphalan
Sign Up to like & getrecommendations! Published in 2017 at "Cardiovascular and Interventional Radiology"
DOI: 10.1007/s00270-017-1766-2
Abstract: Introduction Percutaneous hepatic perfusion (PHP) with melphalan is an effective treatment for patients with hepatic metastases, but associated with high rates of bone marrow depression. To reduce systemic toxicity, improvements have been made to the… read more here.
Keywords: system; hepatic perfusion; delcath system; melphalan ... See more keywords
Intravenous busulfan plus melphalan versus melphalan alone as conditioning regimen for patients with multiple myeloma
Sign Up to like & getrecommendations! Published in 2019 at "Annals of Hematology"
DOI: 10.1007/s00277-019-03663-5
Abstract: Dear Editor, To improve results in transplant-eligible multiple myeloma (MM) patients, the combination of busulfan and melphalan (BUMEL) has been used as an alternative conditioning regimen to standard-dose melphalan 200 mg/m (MEL200) [1–4]. The results… read more here.
Keywords: busulfan; bumel; control; multiple myeloma ... See more keywords
Adsorption behavior of melphalan anti-ovarian cancer drug onto boron nitride nanostructures. Studying MTT assay: in vitro cellular toxicity and viability
Sign Up to like & getrecommendations! Published in 2020 at "Chemical Papers"
DOI: 10.1007/s11696-020-01405-w
Abstract: Ovarian cancer is believed as one of the most fatal reproductive cancers and melphalan has been known to treat this cancer as an intraperitoneal chemotherapeutic agent. Fortunately, nanotechnology enabled us to explore new approaches like… read more here.
Keywords: boron nitride; melphalan; drug; ovarian cancer ... See more keywords
Comparison of mitoxantrone-melphalan and BEAM conditioning regimens in patients with lymphoma.
Sign Up to like & getrecommendations! Published in 2021 at "Hematology/oncology and stem cell therapy"
DOI: 10.1016/j.hemonc.2021.03.005
Abstract: OBJECTIVE/BACKGROUND Lymphoma is seen as a highly treatable and curable malignancy with aggressive treatment methods. Efficacy is often limited by toxicity and many patients need alternative treatment strategies as they cannot tolerate existing high cytotoxic… read more here.
Keywords: patients lymphoma; mel regimen; melphalan; mitoxantrone melphalan ... See more keywords
Co‐delivery of miR‐181a and melphalan by lipid nanoparticles for treatment of seeded retinoblastoma
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Controlled Release"
DOI: 10.1016/j.jconrel.2019.02.014
Abstract: Abstract Melphalan is an efficient chemotherapeutic agent that is currently used to treat retinoblastoma (Rb); however, the inherent risk of immunogenicity and the hazardous integration of this drug in healthy cells is inevitable. MicroRNAs are… read more here.
Keywords: melphalan; retinoblastoma; lipid nanoparticles; gene ... See more keywords
Liposome-Encapsulated Melphalan Exhibits Potent Antimyeloma Activity and Reduced Toxicity
Sign Up to like & getrecommendations! Published in 2022 at "ACS Omega"
DOI: 10.1021/acsomega.2c07555
Abstract: Multiple myeloma (MM), a plasma cell cancer in bone marrow, remains an incurable disease. Melphalan, an alkylating agent, is a conventional anticancer drug that is still widely used for MM treatment in clinics. However, melphalan-induced… read more here.
Keywords: mel; toxicity; melphalan; activity ... See more keywords
Hyperhydration is not necessary for high-dose melphalan in stem cell transplantation
Sign Up to like & getrecommendations! Published in 2019 at "Bone Marrow Transplantation"
DOI: 10.1038/s41409-019-0586-1
Abstract: To the Editor, High-dose melphalan (120–200 mg/m) is widely used in preparative regimens for autologous and allogeneic haematopoietic stem cell transplantation (HSCT). This drug is often given with “hyperhydration” that usually means 4–6 litres (L)… read more here.
Keywords: autologous hsct; hyperhydration; melphalan; transplantation ... See more keywords
Adding bendamustine to melphalan before ASCT improves CR rate in myeloma vs. melphalan alone: A randomized phase-2 trial
Sign Up to like & getrecommendations! Published in 2022 at "Bone Marrow Transplantation"
DOI: 10.1038/s41409-022-01681-y
Abstract: Definite cure remains exceptional in myeloma patients even after high-dose chemotherapy (HDCT) with melphalan (Mel) and autologous stem cell transplantation (ASCT). Thus, improving efficacy of HDCT in MM remains an unresolved issue. This randomized phase… read more here.
Keywords: myeloma; melphalan; phase trial; hdct ... See more keywords
Solution stability of Captisol-stabilized melphalan (Evomela) versus Propylene glycol-based melphalan hydrochloride injection
Sign Up to like & getrecommendations! Published in 2018 at "Pharmaceutical Development and Technology"
DOI: 10.1080/10837450.2016.1265557
Abstract: Abstract Purpose: The objective of this study was to compare the stability of recently approved Captisol-stabilized propylene glycol-free melphalan injection (Evomela™) against currently marketed propylene glycol-based melphalan injection. The products were compared as reconstituted solutions… read more here.
Keywords: melphalan; glycol based; propylene glycol; injection ... See more keywords