From hybrid fibers to microfibers: The characteristics of polyamide 6/polypropylene blend via one‐step twin‐screw melt extrusion
Sign Up to like & getrecommendations! Published in 2020 at "Polymer Engineering and Science"
DOI: 10.1002/pen.25327
Abstract: Multimaterial textiles are frequently employed to attain a certain function or aesthetic effect. The multimaterial assemblies face recycling limitations due to challenges to sort and separate the component materials. A one‐step melt extrusion approach to… read more here.
Keywords: melt extrusion; hybrid fibers; one step; pa6 ... See more keywords
Melt Extrusion of High-Dose Co-Amorphous Drug-Drug Combinations
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DOI: 10.1007/s11095-017-2254-8
Abstract: PurposeMany future drug products will be based on innovative manufacturing solutions, which will increase the need for a thorough understanding of the interplay between drug material properties and processability. In this study, hot melt extrusion… read more here.
Keywords: phase separation; melt extrusion; drug; indomethacin cimetidine ... See more keywords
Development of Fast-Dissolving Amorphous Solid Dispersion of Itraconazole by Melt Extrusion of its Mixture with Weak Organic Carboxylic Acid and Polymer
Sign Up to like & getrecommendations! Published in 2018 at "Pharmaceutical Research"
DOI: 10.1007/s11095-018-2407-4
Abstract: PurposeThe purpose of this study was to explore the feasibility of developing amorphous solid dispersion (ASD) by inducing acid-base interaction at an elevated temperature using hot melt extrusion.MethodsItraconazole and glutaric acid, which do not form salt… read more here.
Keywords: melt extrusion; solid dispersion; itraconazole; amorphous solid ... See more keywords
Improving Pellet Quality in a Pharmaceutical Hot Melt Extrusion Process via PID Control and LOLIMOT-Based MPC
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Pharmaceutical Innovation"
DOI: 10.1007/s12247-019-09417-0
Abstract: Purpose The aim of this paper is the development of a process control concept for a hot melt extrusion (HME) and pelletization process. The new concept should improve the particle size distribution of the pellets… read more here.
Keywords: particle size; quality; melt extrusion; control ... See more keywords
Effect of encapsulation with zeolite and coating with TiO2 on the thermal stability of caffeine during melt extrusion of a PET/TiO2@(zeolite/caffeine) nanocomposite
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DOI: 10.1016/j.apt.2019.01.015
Abstract: Abstract The practice of encapsulating a functional material in a thermally stable porous material displays great potential in preventing decomposition during high-temperature processing. In this study, caffeine encapsulated in zeolite was coated with TiO2 to… read more here.
Keywords: melt extrusion; coating tio2; tio2; caffeine ... See more keywords
A novel in silico scale-up approach for hot melt extrusion processes
Sign Up to like & getrecommendations! Published in 2019 at "Chemical Engineering Science"
DOI: 10.1016/j.ces.2019.04.016
Abstract: Abstract The goal of our study was to develop a rational in silico scale-up and process transfer approach for hot melt extrusion processes occurring in the pharmaceutical and other industries. To that end, we performed… read more here.
Keywords: silico scale; melt extrusion; melt; hot melt ... See more keywords
Chemically identical but physically different: A comparison of spray drying, hot melt extrusion and cryo‐milling for the formulation of high drug loaded amorphous solid dispersions of naproxen
Sign Up to like & getrecommendations! Published in 2019 at "European Journal of Pharmaceutics and Biopharmaceutics"
DOI: 10.1016/j.ejpb.2018.12.002
Abstract: Graphical abstract Figure. No Caption available. Abstract In spite of the large research efforts in the past two decades, it is still difficult, if possible at all, to predict what manufacturing technology will lead to… read more here.
Keywords: drug; high drug; melt extrusion; hot melt ... See more keywords
Melt extrusion vs. spray drying: The effect of processing methods on crystalline content of naproxen‐povidone formulations
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Pharmaceutical Sciences"
DOI: 10.1016/j.ejps.2017.02.038
Abstract: &NA; Our hypothesis is that melt extrusion is a more suitable processing method than spray drying to prepare amorphous solid dispersions of drugs with a high crystallization tendency. Naproxen‐povidone K25 was used as the model… read more here.
Keywords: melt extrusion; spray; processing; naproxen povidone ... See more keywords
Dual‐mechanism gastroretentive drug delivery system loaded with an amorphous solid dispersion prepared by hot‐melt extrusion
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Pharmaceutical Sciences"
DOI: 10.1016/j.ejps.2017.02.040
Abstract: &NA; In the present study, we aimed to prepare a gastroretentive drug delivery system that would be both highly resistant to gastric emptying via multiple mechanisms and would also potentially induce in situ supersaturation. The… read more here.
Keywords: pubchem cid; melt extrusion; delivery system; drug delivery ... See more keywords
Rheological analysis of itraconazole‐polymer mixtures to determine optimal melt extrusion temperature for development of amorphous solid dispersion
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Pharmaceutical Sciences"
DOI: 10.1016/j.ejps.2017.10.034
Abstract: ABSTRACT The objective of this investigation was to develop a systematic method for the determination of optimal processing temperatures of drug‐polymer mixtures for the development of amorphous solid dispersion (ASD) by melt extrusion. Since melt… read more here.
Keywords: melt extrusion; drug polymer; polymer; drug ... See more keywords
Development of stability-enhanced ternary solid dispersions via combinations of HPMCP and Soluplus® processed by hot melt extrusion.
Sign Up to like & getrecommendations! Published in 2017 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2017.09.035
Abstract: The aim of this study was to evaluate a novel combination of hydroxypropyl methylcellulose phthalate (HPMCP-HP-50) and Soluplus® polymers for enhanced physicochemical stability and solubility of the produced amorphous solid dispersions (ASDs). This was achieved… read more here.
Keywords: melt extrusion; solid dispersions; hpmcp soluplus; hot melt ... See more keywords