Memantine protects against ischemia/reperfusion‐induced brain endothelial permeability
Sign Up to like & getrecommendations! Published in 2018 at "IUBMB Life"
DOI: 10.1002/iub.1729
Abstract: Increased transendothelial permeability and subsequent blood–brain barrier damage play a key role in the pathological progression of human brain ischemia and secondary reperfusion. Memantine is a licensed drug providing clinically relevant efficacy in patients with… read more here.
Keywords: endothelial permeability; reperfusion; expression; brain ... See more keywords
Memantine can relieve the neuronal impairment caused by neurotropic virus infection
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Medical Virology"
DOI: 10.1002/jmv.25396
Abstract: Neurotropic viruses, such as the rabies virus (RABV) and Japanese encephalitis virus (JEV), induce neuronal dysfunction and complication, causing neuronal damage. Currently, there are still no effective clinical treatments for neuronal injury caused by neurotropic… read more here.
Keywords: relieve neuronal; caused neurotropic; memantine relieve; mice ... See more keywords
Memantine-Loaded PEGylated Biodegradable Nanoparticles for the Treatment of Glaucoma.
Sign Up to like & getrecommendations! Published in 2018 at "Small"
DOI: 10.1002/smll.201701808
Abstract: Glaucoma is a multifactorial neurodegenerative disease associated with retinal ganglion cells (RGC) loss. Increasing reports of similarities in glaucoma and other neurodegenerative conditions have led to speculation that therapies for brain neurodegenerative disorders may also… read more here.
Keywords: memantine loaded; mem nps; treatment; glaucoma ... See more keywords
Memantine in neurological disorders - schizophrenia and depression.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of molecular medicine"
DOI: 10.1007/s00109-020-01982-z
Abstract: Memantine is used in Alzheimer's disease treatment as a non-competitive modern-affinity strong voltage-dependent N-methyl-D-aspartate receptor antagonist. The fundamental role of these receptors is to bind glutamate: the main excitatory neurotransmitter in the brain, believed to… read more here.
Keywords: memantine neurological; disorders schizophrenia; neurological disorders; schizophrenia depression ... See more keywords
Memantine treatment does not affect compulsive behavior or frontostriatal connectivity in an adolescent rat model for quinpirole-induced compulsive checking behavior.
Sign Up to like & getrecommendations! Published in 2022 at "Psychopharmacology"
DOI: 10.1007/s00213-022-06139-z
Abstract: RATIONALE Compulsivity often develops during childhood and is associated with elevated glutamate levels within the frontostriatal system. This suggests that anti-glutamatergic drugs, like memantine, may be an effective treatment. OBJECTIVE Our goal was to characterize… read more here.
Keywords: memantine treatment; compulsive checking; treatment; memantine ... See more keywords
Prescription of memantine during non-stereotactic, brain-directed radiation among patients with brain metastases: a population-based study
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Neuro-Oncology"
DOI: 10.1007/s11060-020-03542-4
Abstract: Purpose Whole brain radiation therapy (WBRT) remains an important component of treatment for patients with multiple brain metastases (BrM) but is associated with significant neurotoxicity and memory impairment. Although RTOG 0614 demonstrated that administration of… read more here.
Keywords: stereotactic brain; non stereotactic; brain directed; brain ... See more keywords
Memantine, a Noncompetitive N-Methyl-d-Aspartate Receptor Antagonist, Attenuates Cerebral Amyloid Angiopathy by Increasing Insulin-Degrading Enzyme Expression
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DOI: 10.1007/s12035-019-01678-7
Abstract: Sporadic cerebral amyloid angiopathy (CAA) is characterized by cerebrovascular amyloid beta (Aβ) deposits and causes cerebral hemorrhages and dementia in elderly people. Memantine is used in Alzheimer’s disease to inhibit the glutamatergic system by blocking… read more here.
Keywords: amyloid angiopathy; cerebral amyloid; methyl aspartate; degrading enzyme ... See more keywords
Pragmatic recruitment of memantine as the capping group for the design of HDAC inhibitors: A preliminary attempt to unravel the enigma of glioblastoma.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2021.113338
Abstract: Hurdled and marred by the notorious nature of glioblastomas (GBM) in terms of resistance to therapy and limited drug delivery into the brain, the anti-GBM drug pipeline is required to be loaded with mechanistically diverse… read more here.
Keywords: gbm; group; hdac inhibitors; gbm cells ... See more keywords
Combined treatment with escitalopram and memantine increases gray matter volume and cortical thickness compared to escitalopram and placebo in a pilot study of geriatric depression.
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DOI: 10.1016/j.jad.2020.05.092
Abstract: BACKGROUND Geriatric depression with subjective cognitive complaints increases the risk of Alzheimer's Disease (AD). Memantine is a cognitive enhancer used to treat AD. In a 6-month double-blind randomized placebo-controlled trial of escitalopram and memantine (ESC/MEM),… read more here.
Keywords: geriatric depression; esc; memantine; esc mem ... See more keywords
RESOLUTION OF INAPPROPRIATE SEXUAL BEHAVIOR IN AN ELDERLY MALE WITH MAJOR NEUROCOGNITIVE DISORDER AND DEVELOPMENTAL DELAY WITH MEMANTINE
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DOI: 10.1016/j.jagp.2020.01.109
Abstract: Introduction Memantine is a non-competitive N-methyl-d-aspartate receptor antagonist approved for the treatment of moderate to severe Alzheimer's disease(AD). There is a dearth of literature about the emergence of a major neurocognitive disorder in older individuals… read more here.
Keywords: developmental delay; isb; major neurocognitive; memantine ... See more keywords
The effects of memantine on the serum concentrations of matrix metalloproteinases and neurologic function of patients with ischemic stroke
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Clinical Neuroscience"
DOI: 10.1016/j.jocn.2021.06.005
Abstract: Memantine was suggested as a promising treatment for stroke due to its neuroprotective property and efficacy in reducing ischemic brain injury and improving post-ischemic neurological recovery. This pilot, open-label, randomized clinical trial was conducted to… read more here.
Keywords: ischemic stroke; serum concentrations; function patients; memantine ... See more keywords