Multifunctional memantine nitrate significantly protects against glutamate-induced excitotoxicity via inhibiting calcium influx and attenuating PI3K/Akt/GSK3beta pathway.
Sign Up to like & getrecommendations! Published in 2020 at "Chemico-biological interactions"
DOI: 10.1016/j.cbi.2020.109020
Abstract: Alzheimer's disease (AD), characterized by impairment of cognitive functions, mainly affects the elderly worldwide. We have previously designed and synthesized a series of memantine nitrate derivatives with vessel dilatory effects. Some of novel compounds have… read more here.
Keywords: glutamate induced; induced excitotoxicity; memantine nitrate; calcium ... See more keywords
Therapeutic efficacy of novel memantine nitrate MN‐08 in animal models of Alzheimer’s disease
Sign Up to like & getrecommendations! Published in 2021 at "Aging Cell"
DOI: 10.1111/acel.13371
Abstract: Alzheimer's disease (AD) is a leading cause of dementia in elderly individuals and therapeutic options for AD are very limited. Over‐activation of N‐methyl‐D‐aspartate (NMDA) receptors, amyloid β (Aβ) aggregation, a decrease in cerebral blood flow… read more here.
Keywords: alzheimer disease; novel memantine; memantine nitrate;