Multifunctional memantine nitrate significantly protects against glutamate-induced excitotoxicity via inhibiting calcium influx and attenuating PI3K/Akt/GSK3beta pathway.
Sign Up to like & getrecommendations! Published in 2020 at "Chemico-biological interactions"
DOI: 10.1016/j.cbi.2020.109020
Abstract: Alzheimer's disease (AD), characterized by impairment of cognitive functions, mainly affects the elderly worldwide. We have previously designed and synthesized a series of memantine nitrate derivatives with vessel dilatory effects. Some of novel compounds have… read more here.
Keywords: glutamate induced; induced excitotoxicity; memantine nitrate; calcium ... See more keywords
Neuroprotective and intraocular pressure lowering effects of dual-functional memantine nitrate MN-08 on the experimental models of glaucoma
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DOI: 10.1038/s41598-025-06832-x
Abstract: Glaucoma stands out as the primary cause of permanent blindness worldwide, marked by elevated intraocular pressure (IOP) and the deterioration of retinal ganglion cells (RGCs) within the optic nerve. This study aimed to investigate the… read more here.
Keywords: models glaucoma; experimental models; memantine nitrate; intraocular pressure ... See more keywords
Therapeutic efficacy of novel memantine nitrate MN‐08 in animal models of Alzheimer’s disease
Sign Up to like & getrecommendations! Published in 2021 at "Aging Cell"
DOI: 10.1111/acel.13371
Abstract: Alzheimer's disease (AD) is a leading cause of dementia in elderly individuals and therapeutic options for AD are very limited. Over‐activation of N‐methyl‐D‐aspartate (NMDA) receptors, amyloid β (Aβ) aggregation, a decrease in cerebral blood flow… read more here.
Keywords: alzheimer disease; novel memantine; memantine nitrate;