Pd-Catalyzed Amination of Base-Sensitive Five-Membered Heteroaryl Halides with Aliphatic Amines.
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DOI: 10.1021/jacs.2c13520
Abstract: We report a versatile and functional-group-tolerant method for the Pd-catalyzed C-N cross-coupling of five-membered heteroaryl halides with primary and secondary amines, an important but underexplored transformation. Coupling reactions of challenging, pharmaceutically relevant heteroarenes, such as… read more here.
Keywords: five membered; membered heteroaryl; heteroaryl halides; sensitive five ... See more keywords