Palladium-catalyzed diastereoselective cross-coupling of two aryl halides via C-H activation: synthesis of chiral eight-membered nitrogen heterocycles.
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DOI: 10.1039/d1cc00398d
Abstract: A method for the synthesis of enantiopure eight-membered nitrogen heterocycles has been developed through diastereoselective cross-coupling of 2-iodobiphenyls with 2-bromobenzylamines. The products represent a novel type of chiral scaffold, which feature easy modification and high… read more here.
Keywords: nitrogen heterocycles; membered nitrogen; eight membered; diastereoselective cross ... See more keywords