Identification of N‐Arylated NH125 Analogues as Rapid Eradicating Agents against MRSA Persister Cells and Potent Biofilm Killers of Gram‐Positive Pathogens
Sign Up to like & getrecommendations! Published in 2017 at "ChemBioChem"
DOI: 10.1002/cbic.201600622
Abstract: Bacterial biofilms housing dormant persister cells are innately tolerant to antibiotics and disinfectants, yet several membrane‐active agents are known to eradicate tolerant bacterial cells. NH125, a membrane‐active persister killer and starting point for development, led… read more here.
Keywords: agents mrsa; membrane active; persister cells; persister ... See more keywords
Mechanism of Action of pH-Triggered Membrane Active Peptides
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2016.11.2839
Abstract: The plasma membrane insulates a cell from its outside environment, serving as a selectively impermeable barrier across which only small or hydrophobic molecules can pass. Although the membrane is necessary for life, it is also… read more here.
Keywords: membrane active; triggered membrane; action triggered; active peptides ... See more keywords
Molecular State of the Membrane-Active Antibiotic Daptomycin.
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical journal"
DOI: 10.1016/j.bpj.2017.05.025
Abstract: Membrane-active antibiotics are potential alternatives to the resistance-prone conventional antibiotics. Daptomycin, a cyclic lipopeptide, is the only membrane-active antibiotic approved by the U.S. Food and Drug Administration so far. The drug interacts with the cytoplasmic… read more here.
Keywords: membrane active; membrane binding; calcium; daptomycin ... See more keywords
Computational design of the helical hairpin structure of membrane-active antibacterial peptides based on RSV glycoprotein epitope scaffold
Sign Up to like & getrecommendations! Published in 2018 at "Computational biology and chemistry"
DOI: 10.1016/j.compbiolchem.2018.02.013
Abstract: Peptides with helical hairpin conformation have been found to possess potent membrane activity and can be exploited as the structural scaffold of antibacterial peptides (ABPs). Here, we attempted to computationally design membrane-active ABPs based on… read more here.
Keywords: membrane active; hairpin; rsv glycoprotein; antibacterial peptides ... See more keywords
Membrane-Active Molecular Machines.
Sign Up to like & getrecommendations! Published in 2022 at "Accounts of chemical research"
DOI: 10.1021/acs.accounts.1c00804
Abstract: ConspectusBoth biological and artificial membrane transporters mediate passive transmembrane ion flux predominantly via either channel or carrier mechanisms, tightly regulating the transport of materials entering and exiting the cell. One early elegant example unclassifiable as… read more here.
Keywords: ion swimmers; membrane; membrane active; molecular machines ... See more keywords
Mitigation of Thin-Film Composite Membrane Biofouling via Immobilizing Nano-Sized Biocidal Reservoirs in the Membrane Active Layer.
Sign Up to like & getrecommendations! Published in 2017 at "Environmental science & technology"
DOI: 10.1021/acs.est.7b00782
Abstract: This work investigates the use of a silver-based metal-organic framework (MOF) for mitigating biofouling in forward-osmosis thin-film composite (TFC) membranes. This is the first study of the use of MOFs for biofouling control in membranes.… read more here.
Keywords: membrane active; microscopy; layer; thin film ... See more keywords
In Vitro and in Vivo Evaluation of Membrane-Active Flavone Amphiphiles: Semisynthetic Kaempferol-Derived Antimicrobials against Drug-Resistant Gram-Positive Bacteria.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.0c00053
Abstract: The rapid increase in bacterial resistance requires an urgent need for developing new antimicrobial agents to combat multidrug-resistant pathogens. In this study, we designed and synthesized a series of kaempferol derivatives as antimicrobial agents biomimicking… read more here.
Keywords: gram positive; membrane active; kaempferol; positive bacteria ... See more keywords
Application of the All-Hydrocarbon Stapling Technique in the Design of Membrane-Active Peptides.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.1c01744
Abstract: The threats of drug resistance and new emerging pathogens have led to an urgent need to develop alternative treatment therapies. Recently, considerable research efforts have focused on membrane-active peptides (MAPs), a category of peptides in… read more here.
Keywords: active peptides; hydrocarbon stapling; membrane active; design ... See more keywords
Mycobacterial Membranes as Actionable Targets for Lipid-Centric Therapy in Tuberculosis.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.1c01870
Abstract: Infectious diseases remain significant health concerns worldwide, and resistance is particularly common in patients with tuberculosis caused by Mycobacterium tuberculosis. The development of anti-infectives with novel modes of action may help overcome resistance. In this… read more here.
Keywords: tuberculosis; membrane active; membranes actionable; mycobacterial membranes ... See more keywords
Hydrophilic Phage-Mimicking Membrane Active Antimicrobials Reveal Nanostructure-Dependent Activity and Selectivity.
Sign Up to like & getrecommendations! Published in 2017 at "ACS infectious diseases"
DOI: 10.1021/acsinfecdis.7b00076
Abstract: The prevalent wisdom on developing membrane active antimicrobials (MAAs) is to seek a delicate, yet unquantified, cationic-hydrophobic balance. Inspired by phages that use nanostructured protein devices to invade bacteria efficiently and selectively, we study here… read more here.
Keywords: membrane active; active antimicrobials; activity selectivity; hydrophilic phage ... See more keywords
Lipid-specific interactions determine the organization and dynamics of membrane-active peptide melittin.
Sign Up to like & getrecommendations! Published in 2020 at "Soft matter"
DOI: 10.1039/d0sm00046a
Abstract: The cell membranes of different cells deviate significantly in lipid compositions and thus provide varying biological environments to modulate the diffusion, organization and the resultant function of biomacromolecules. However, the detailed modulation mechanism remains elusive… read more here.
Keywords: membrane active; peptide; organization dynamics; melittin ... See more keywords