Contributions of Glycosaminoglycans to Membrane Adsorption and Conformational Conversion of Peptide Hormones
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DOI: 10.1016/j.bpj.2016.11.1062
Abstract: The membrane catalysis hypothesis advocates that a peptide ligand initially interacts with the plasma membrane and this interaction increases the local concentration at the vicinity of its cognate receptor. Besides, upon membrane adsorption, the peptide… read more here.
Keywords: adsorption; membrane catalysis; membrane adsorption; peptide hormones ... See more keywords
Amphiphiles capsaicin and triton X-100 regulate the chemotherapy drug colchicine’s membrane adsorption and ion pore formation potency☆
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DOI: 10.1016/j.sjbs.2021.02.054
Abstract: Chemotherapy drugs (CDs), e.g. colchicine derivative thiocolchicoside (TCC) and taxol, have been found to physically bind with lipid bilayer membrane and induce ion pores. Amphiphiles capsaicin (Cpsn) and triton X-100 (TX100) are known to regulate… read more here.
Keywords: potency; membrane adsorption; ion; membrane ... See more keywords
Phospholipase Cβ3 Membrane Adsorption and Activation Are Regulated by Its C-Terminal Domains and Phosphatidylinositol 4,5-Bisphosphate.
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DOI: 10.1021/acs.biochem.7b00547
Abstract: Phospholipase Cβ (PLCβ) enzymes hydrolyze phosphatidylinositol 4,5-bisphosphate to produce second messengers that regulate intracellular Ca2+, cell proliferation, and survival. Their activity is dependent upon interfacial activation that occurs upon localization to cell membranes. However, the… read more here.
Keywords: adsorption; membrane adsorption; phospholipase; phosphatidylinositol bisphosphate ... See more keywords