Engineering of a critical membrane-anchored enzyme for high solubility and catalytic activity.
Sign Up to like & getrecommendations! Published in 2021 at "Archives of biochemistry and biophysics"
DOI: 10.1016/j.abb.2021.108870
Abstract: Membrane-associated proteins carry out a wide range of essential cellular functions but the structural characterization needed to understand these functions is dramatically underrepresented in the Protein Data Bank. Producing a soluble, stable and active form… read more here.
Keywords: engineering critical; anchored enzyme; form; critical membrane ... See more keywords
A cell membrane-anchored DNA nano-platform for programming cellular interactions.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.9b04725
Abstract: Cell-cell interactions are mediated through compositions expressed on the membrane. Engineering the cell surface to display functional modules with high biocompatibility, high controllability and high stability, would offer great opportunities for studying and manipulating these… read more here.
Keywords: cell membrane; dna; nano platform; cell ... See more keywords
A membrane-anchored aptamer sensor for probing IFNγ secretion by single cells.
Sign Up to like & getrecommendations! Published in 2017 at "Chemical communications"
DOI: 10.1039/c7cc03576d
Abstract: Insight into the behavior of individual immune cells, in particular cytokine secretion, will contribute to a more fundamental understanding of the immune system. In this work, we have developed a cell membrane-anchored sensor for the… read more here.
Keywords: aptamer sensor; anchored aptamer; secretion; single cells ... See more keywords
A cell membrane-anchored fluorescent probe for monitoring carbon monoxide release from living cells† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c8sc03584a
Sign Up to like & getrecommendations! Published in 2019 at "Chemical Science"
DOI: 10.1039/c8sc03584a
Abstract: A novel cell membrane-anchored probe (ANRP) was constructed to monitor CO release from living cells for the first time. read more here.
Keywords: release living; cell membrane; membrane anchored; living cells ... See more keywords
Selective targeting of metastatic ovarian cancer using an engineered anthrax prodrug activated by membrane-anchored serine proteases
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2201423119
Abstract: Significance Ovarian cancer is the most lethal gynecological cancer. Clinically approved chemotherapies aim to slow or stop tumor growth; however, cancer cells continue to evolve between chemotherapy cycles, acquiring properties that allow cell survival and… read more here.
Keywords: metastatic ovarian; ovarian cancer; anchored serine; membrane anchored ... See more keywords
Development of new tools to study membrane-anchored mammalian Atg8 proteins
Sign Up to like & getrecommendations! Published in 2022 at "Autophagy"
DOI: 10.1080/15548627.2022.2132040
Abstract: ABSTRACT Mammals conserve multiple mammalian Atg8-family proteins (mATG8s) consisting of GABARAP (GABA type A receptor-associated protein) and MAP1LC3/LC3 (microtubule associated protein 1 light chain 3) subfamilies that tightly bind to autophagic membranes in a membrane-anchored… read more here.
Keywords: membrane; membrane anchored; mammalian atg8; associated protein ... See more keywords
Cell membrane-anchored and tumor-targeted IL-12 (attIL12)-T cell therapy for eliminating large and heterogeneous solid tumors
Sign Up to like & getrecommendations! Published in 2022 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2021-003633
Abstract: Background Adoptive T-cell transfer has become an attractive therapeutic approach for hematological malignancies but shows poor activity against large and heterogeneous solid tumors. Interleukin-12 (IL-12) exhibits potent antitumor efficacy against solid tumors, but its clinical… read more here.
Keywords: cell; large heterogeneous; cell membrane; solid tumors ... See more keywords