Membrane-Anchoring, Comb-Like Pseudopeptides for Efficient, pH-Mediated Membrane Destabilization and Intracellular Delivery.
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DOI: 10.1021/acsami.7b00498
Abstract: Endosomal release has been identified as a rate-limiting step for intracellular delivery of therapeutic agents, in particular macromolecular drugs. Herein, we report a series of synthetic pH-responsive, membrane-anchoring polymers exhibiting dramatic endosomolytic activity for efficient… read more here.
Keywords: delivery; intracellular delivery; membrane destabilization; membrane anchoring ... See more keywords
Membrane anchoring facilitates colocalization of enzymes in plant cytochrome P450 redox systems
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DOI: 10.1038/s42003-021-02604-1
Abstract: Plant metabolism depends on cascade reactions mediated by dynamic enzyme assemblies known as metabolons. In this context, the cytochrome P450 (P450) superfamily catalyze key reactions underpinning the unique diversity of bioactive compounds. In contrast to… read more here.
Keywords: plant; p450; membrane anchoring; cytochrome p450 ... See more keywords
The Membrane-Anchoring Region of the AcMNPV P74 Protein Is Expendable or Interchangeable with Homologs from Other Species
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DOI: 10.3390/v13122416
Abstract: Baculoviruses are insect pathogens that are characterized by assembling the viral dsDNA into two different enveloped virions during an infective cycle: occluded virions (ODVs; immersed in a protein matrix known as occlusion body) and budded… read more here.
Keywords: p74; region acmnpv; anchoring region; region ... See more keywords