Modeling Membrane Associated Proteins through Neutron Reflectivity Augmented Molecular Dynamics
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2016.11.770
Abstract: The structural characterization of membrane-associated proteins on fluid lipid bilayers remains a challenge to most modern biophysical techniques. Neutron reflectivity (NR) has emerged as a method that provides sub-nanometer resolution of proteins in a functional… read more here.
Keywords: protein; associated proteins; density; neutron reflectivity ... See more keywords
Bisphenol A induces human uterine leiomyoma cell proliferation through membrane-associated ERα36 via nongenomic signaling pathways
Sign Up to like & getrecommendations! Published in 2019 at "Molecular and Cellular Endocrinology"
DOI: 10.1016/j.mce.2019.01.001
Abstract: The role of ERα36 in regulating BPA's effects and its potential as a risk factor for human uterine fibroids were evaluated. BPA at low concentrations (10-6 μM - 10 μM) increased proliferation by facilitating progression of hormonally… read more here.
Keywords: nongenomic signaling; signaling pathways; proliferation; membrane associated ... See more keywords
Functional expression and purification of CYP93C20, a plant membrane-associated cytochrome P450 from Medicago truncatula.
Sign Up to like & getrecommendations! Published in 2018 at "Protein expression and purification"
DOI: 10.1016/j.pep.2018.04.017
Abstract: Plants possess very large numbers of biosynthetic cytochrome P450 enzymes. In spite of the importance of these enzymes for the synthesis of bioactive plant secondary metabolites, only two plant P450 structures has been obtained to… read more here.
Keywords: plant; expression; membrane associated; cytochrome p450 ... See more keywords
Membrane-Associated RNA-Binding Proteins Orchestrate Organelle-Coupled Translation.
Sign Up to like & getrecommendations! Published in 2019 at "Trends in cell biology"
DOI: 10.1016/j.tcb.2018.10.005
Abstract: Proteins are positioned and act at defined subcellular locations. This is particularly important in eukaryotic cells that deliver proteins to membrane-bound organelles such as the endoplasmic reticulum (ER), mitochondria, or endosomes. It is axiomatic that… read more here.
Keywords: binding proteins; rna binding; translation; membrane associated ... See more keywords
The expression and purification of DGD2 - a chloroplast outer membrane associated glycosyltransferase for galactolipid synthesis.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemistry"
DOI: 10.1021/acs.biochem.0c00028
Abstract: Galactolipids are characteristic lipids of the photosynthetic membranes. They are highly enriched in the chloroplast and are present in photosystem structures. There are two major types of galactolipids, i.e., monogalactosyldiacylglycerol (MGDG) and digalactosyldiacylglycerol (DGDG) in… read more here.
Keywords: dgd2; expression; membrane associated; purification ... See more keywords
Purification and Characterization of a Stable, Membrane-Associated Peptidoglycan Responsive Adenylate Cyclase LRR Domain from Human Commensal Candida albicans.
Sign Up to like & getrecommendations! Published in 2022 at "Biochemistry"
DOI: 10.1021/acs.biochem.2c00305
Abstract: The evolutionarily conserved leucine rich repeat (LRR) protein domain is a unique structural motif found in many viral, bacterial, archaeal, and eukaryotic proteins. The LRR domain serves many roles, including being a signaling domain and… read more here.
Keywords: domain; lrr domain; candida albicans; membrane associated ... See more keywords
Targeting Protein Kinase, Membrane-Associated Tyrosine/Threonine 1 (PKMYT1) for Precision Cancer Therapy: From Discovery to Clinical Trial.
Sign Up to like & getrecommendations! Published in 2024 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.4c01619
Abstract: \Protein kinase membrane-associated tyrosine/threonine 1 (PKMYT1), an overlooked member of the WEE family responsible for regulating cell cycle transition, has recently emerged as a compelling therapeutic target for precision cancer therapy due to its established… read more here.
Keywords: membrane associated; protein kinase; therapy; precision ... See more keywords
Immobilization of Membrane-Associated Protein Complexes on SERS-Active Nanomaterials for Structural and Dynamic Characterization.
Sign Up to like & getrecommendations! Published in 2024 at "Nano letters"
DOI: 10.1021/acs.nanolett.4c04423
Abstract: Exploring the structural basis of membrane proteins is significant for a deeper understanding of protein functions. In situ analysis of membrane proteins and their dynamics, however, still challenges conventional techniques. Here we report the first… read more here.
Keywords: membrane associated; protein; sers active; protein complexes ... See more keywords
Developing Cell-Membrane-Associated Liposomes for Liver Diseases.
Sign Up to like & getrecommendations! Published in 2024 at "ACS nano"
DOI: 10.1021/acsnano.4c12122
Abstract: Over the past decade, a marked escalation in the prevalence of hepatic pathologies has been observed, adversely impacting the quality of life for many. The predominant therapeutic strategy for liver diseases has been pharmacological intervention;… read more here.
Keywords: membrane associated; associated liposomes; cell membrane; liver diseases ... See more keywords
Reconstitution of the Linaridin Pathway Provides Access to the Family-Determining Activity of Two Membrane-Associated Proteins in the Formation of Structurally Underestimated Cypemycin.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.3c01730
Abstract: Cypemycin is a parent linaridin peptide known to contain nonproteinogenic dehydrobutyrine, N,N-dimethylalanine, and aminovinyl-cysteine residues. The enzymatic process by which this ribosomally synthesized peptide is formed remains elusive largely because of the deficiency of knowledge… read more here.
Keywords: membrane associated; two membrane; family determining; activity ... See more keywords
Optineurin is an adaptor protein for ubiquitinated substrates in Golgi membrane-associated degradation
Sign Up to like & getrecommendations! Published in 2025 at "Nature Communications"
DOI: 10.1038/s41467-025-64400-3
Abstract: Golgi membrane-associated degradation (GOMED) is a process that leading to the degradation of proteins that have passed through the trans-Golgi membranes upon Golgi stress. GOMED is morphologically similar to autophagy, but the substrates degraded are… read more here.
Keywords: degradation gomed; membrane associated; degradation; golgi membrane ... See more keywords