The role of complement membrane attack complex in dry and wet AMD - From hypothesis to clinical trials.
Sign Up to like & getrecommendations! Published in 2019 at "Experimental eye research"
DOI: 10.1016/j.exer.2019.05.006
Abstract: Data from human dry and wet age-related macular degeneration (AMD) eyes support the hypothesis that constant 'tickover' of the alternative complement pathway results in chronic deposition of the complement membrane attack complex (MAC) on the… read more here.
Keywords: complement membrane; dry wet; wet amd; membrane attack ... See more keywords
CryoEM reveals how the complement membrane attack complex ruptures lipid bilayers
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-07653-5
Abstract: The membrane attack complex (MAC) is one of the immune system’s first responders. Complement proteins assemble on target membranes to form pores that lyse pathogens and impact tissue homeostasis of self-cells. How MAC disrupts the… read more here.
Keywords: attack complex; complement membrane; lipid bilayers; membrane attack ... See more keywords
Development, Characterization, and in vivo Validation of a Humanized C6 Monoclonal Antibody that Inhibits the Membrane Attack Complex.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of innate immunity"
DOI: 10.1159/000524587
Abstract: Damage and disease of nerves activates the complement system. We demonstrated that activation of the terminal pathway of the complement system leads to the formation of the membrane attack complex (MAC) and delays regeneration in… read more here.
Keywords: monoclonal antibody; disease; membrane attack; formation ... See more keywords
Complement Membrane Attack Complexes Assemble NLRP3 Inflammasomes Triggering IL-1 Activation of IFN-γ-Primed Human Endothelium.
Sign Up to like & getrecommendations! Published in 2019 at "Circulation research"
DOI: 10.1161/circresaha.119.314845
Abstract: RATIONALE Complement activation contributes to multiple immune-mediated pathologies. In late allograft failure, donor-specific antibody deposits complement membrane attack complexes (MAC) on graft endothelial cells (ECs), substantially increasing their immunogenicity without causing lysis. Internalized MAC stabilize… read more here.
Keywords: activation; complement membrane; membrane attack; mac ... See more keywords
Membrane attack complexes, endothelial cell activation, and direct allorecognition
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.1020889
Abstract: Endothelial cells (ECs) form a critical immune interface regulating both the activation and trafficking of alloreactive T cells. In the setting of solid organ transplantation, donor-derived ECs represent sites where alloreactive T cells encounter major… read more here.
Keywords: cell; membrane attack; cell activation; direct allorecognition ... See more keywords
Complement membrane attack complex is an immunometabolic regulator of NLRP3 activation and IL-18 secretion in human macrophages
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.918551
Abstract: The complement system is an ancient and critical part of innate immunity. Recent studies have highlighted novel roles of complement beyond lysis of invading pathogens with implications in regulating the innate immune response, as well… read more here.
Keywords: complement; membrane attack; regulator; attack complex ... See more keywords