Recombinant production, bioconjugation and membrane binding studies ofPn3a, a selective NaV1.7 inhibitor.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical pharmacology"
DOI: 10.1016/j.bcp.2020.114148
Abstract: Chronic pain is a common and often debilitating condition. Existing treatments are either inefficacious or associated with a wide range of side effects. The progress on developing safer and more effective analgesics has been slow,… read more here.
Keywords: inhibitor; recombinant production; membrane binding; membrane ... See more keywords
Membrane Binding and Antimicrobial Activity of a Catioinc, Porphyrin-Binding Peptide
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2016.11.2066
Abstract: A designed catioinic, amphiphilic peptide was previously shown to bind porphyrin molecules and promote the formation of excitonically coupled J-aggregate structures (Caputo et. al. 2009). Due to the catioinic and amphiphilic nature, this peptide was… read more here.
Keywords: antimicrobial activity; membrane binding; porphyrin; activity ... See more keywords
Molecular State of the Membrane-Active Antibiotic Daptomycin.
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical journal"
DOI: 10.1016/j.bpj.2017.05.025
Abstract: Membrane-active antibiotics are potential alternatives to the resistance-prone conventional antibiotics. Daptomycin, a cyclic lipopeptide, is the only membrane-active antibiotic approved by the U.S. Food and Drug Administration so far. The drug interacts with the cytoplasmic… read more here.
Keywords: membrane active; membrane binding; calcium; daptomycin ... See more keywords
Estimating the Accuracy of the Martini Model Towards the Investigation of Peripheral Protein - Membrane Interactions
Sign Up to like & getrecommendations! Published in 2021 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2020.11.1540
Abstract: Peripheral membrane proteins play a major role in numerous biological processes by transiently associating with cellular membranes, often with extreme membrane specificity. Because of the short-lived nature of these interactions, molecular dynamics (MD) simulations have… read more here.
Keywords: peripheral proteins; protein membrane; estimating accuracy; membrane ... See more keywords
Simulations of Kindlin-2 PIP Binding Domains Reveal Protonation-Dependent Membrane Binding Modes.
Sign Up to like & getrecommendations! Published in 2021 at "Biophysical journal"
DOI: 10.1016/j.bpj.2021.11.021
Abstract: Kindlin-2, a member of the Kindlin family of peripheral membrane proteins, is important for integrin activation and stabilization of epidermal growth factor receptor. It associates with the cytoplasmic face of the plasma membrane via dedicated… read more here.
Keywords: phosphatidylinositol; binding domains; membrane binding; protonation ... See more keywords
Bactericidal activity of fish galectin 4 derived membrane‐binding peptide tagged with oligotryptophan
Sign Up to like & getrecommendations! Published in 2017 at "Developmental and Comparative Immunology"
DOI: 10.1016/j.dci.2017.01.019
Abstract: ABSTRACT Galectins belong to the family of galactoside‐binding proteins which act as pathogen recognition receptors by recognizing and binding to the carbohydrate present in the bacterial membranes. In this study, a Galectin‐4 sequence was identified… read more here.
Keywords: binding peptide; membrane binding; membrane; activity ... See more keywords
CTP regulates membrane-binding activity of the nucleoid occlusion protein Noc
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Cell"
DOI: 10.1016/j.molcel.2021.06.025
Abstract: Summary ATP- and GTP-dependent molecular switches are extensively used to control functions of proteins in a wide range of biological processes. However, CTP switches are rarely reported. Here, we report that a nucleoid occlusion protein… read more here.
Keywords: membrane binding; ctp; nucleoid occlusion; binding activity ... See more keywords
A Comparative Analysis of the Membrane Binding and Remodeling Properties of Two Related Sorting Nexin Complexes Involved in Autophagy.
Sign Up to like & getrecommendations! Published in 2022 at "Biochemistry"
DOI: 10.1021/acs.biochem.2c00007
Abstract: The sorting nexin (SNX) proteins, Atg20 and Atg24, are involved in nonselective autophagy, are necessary for efficient selective autophagy, and are required for the cytoplasm-to-vacuole transport pathway. However, the specific roles of these proteins in… read more here.
Keywords: atg20 atg24; binding remodeling; remodeling properties; sorting nexin ... See more keywords
Differential Membrane Binding Mechanics of Synaptotagmin Isoforms Observed in Atomic Detail.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemistry"
DOI: 10.1021/acs.biochem.6b00468
Abstract: Synaptotagmin (Syt) is a membrane-associated protein involved in vesicle fusion through the SNARE complex that is found throughout the human body in 17 different isoforms. These isoforms have two membrane-binding C2 domains, which sense Ca2+… read more here.
Keywords: differential membrane; binding mechanics; membrane binding; syt ... See more keywords
Lipid Membrane Binding and Cell Protection Efficacy of Poly(1,2-butylene oxide)-b-poly(ethylene oxide) Copolymers.
Sign Up to like & getrecommendations! Published in 2022 at "Biomacromolecules"
DOI: 10.1021/acs.biomac.1c01661
Abstract: Poloxamers consisting of poly(ethylene oxide) (PEO) and poly(propylene oxide) segments can protect cell membranes against various forms of stress. We investigated the role of the hydrophobic block chemistry on polymer/membrane binding and cell membrane protection… read more here.
Keywords: ethylene oxide; cell; protection; poly ethylene ... See more keywords
Stepwise membrane binding of extended synaptotagmins revealed by optical tweezers
Sign Up to like & getrecommendations! Published in 2021 at "Nature Chemical Biology"
DOI: 10.1038/s41589-021-00914-3
Abstract: Extended synaptotagmins (E-Syts) mediate lipid exchange between the endoplasmic reticulum (ER) and the plasma membrane (PM). Anchored on the ER, E-Syts bind the PM via an array of C2 domains in a Ca2+- and lipid-dependent… read more here.
Keywords: membrane; extended synaptotagmins; stepwise membrane; membrane binding ... See more keywords