Purification of Histidine-Tagged Membrane-Bound Catechol-O-Methyltransferase from Detergent-Solubilized Pichia pastoris Membranes
Sign Up to like & getrecommendations! Published in 2018 at "Chromatographia"
DOI: 10.1007/s10337-017-3453-5
Abstract: Catechol-O-methyltransferase (COMT) is an enzyme involved in catecholamine catabolism that is key for the treatment of different neurologic disorders. Actually, there are still unmet needs concerning the development of more selective membrane-bound COMT (hMBCOMT) downstream… read more here.
Keywords: pastoris membranes; membrane bound; catechol methyltransferase; hmbcomt ... See more keywords
Prothrombinase: the paradigm for membrane bound enzyme complexes; a memoir
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Thrombosis and Thrombolysis"
DOI: 10.1007/s11239-021-02451-1
Abstract: This review is a brief summary of the history of the development of the Prothrombinase complex paradigm and its incorporation into the “extrinsic pathway”. It summarizes my laboratory’s research from 1968 to 2012 and identifies… read more here.
Keywords: paradigm; paradigm membrane; membrane bound; bound enzyme ... See more keywords
The Inactivation Kinetics of Soluble and Membrane-Bound Polyphenol Oxidase in Pear during Thermal and High-Pressure Processing
Sign Up to like & getrecommendations! Published in 2018 at "Food and Bioprocess Technology"
DOI: 10.1007/s11947-018-2070-0
Abstract: Polyphenol oxidase (PPO) from pear was characterized with catechol as substrate. The Michaelis constant of soluble and membrane-bound PPO were 15.6 and 23.8 mM, respectively, and their optimum pH for activity were 6.0 and 6.5, respectively.… read more here.
Keywords: inactivation; high pressure; soluble membrane; membrane bound ... See more keywords
Unbalanced expression of membrane-bound and soluble inducible costimulator and programmed cell death 1 in patients with myasthenia gravis.
Sign Up to like & getrecommendations! Published in 2019 at "Clinical immunology"
DOI: 10.1016/j.clim.2019.07.011
Abstract: This study aimed to investigate the possible functions and mechanisms of positive and negative costimulatory molecules in the pathological process of myasthenia gravis (MG). The expression levels of membrane-bound inducible costimulator (ICOS) and programmed cell… read more here.
Keywords: sicosl spd; membrane bound; group; usmg group ... See more keywords
Pyridazinone-substituted benzenesulfonamides display potent inhibition of membrane-bound human carbonic anhydrase IX and promising antiproliferative activity against cancer cell lines.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2019.02.044
Abstract: An expanded set of pyridazine-containing benzene sulfonamides was investigated for inhibition of four human carbonic anhydrase isoforms, which revealed a pronounced inhibition trend toward hCA IX, a cancer-related, membrane-bound isoform of the enzyme. Comparison of… read more here.
Keywords: carbonic anhydrase; human carbonic; membrane bound; inhibition ... See more keywords
NADPH oxidase: A membrane-bound enzyme and its inhibitors in diabetic complications.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2020.173206
Abstract: The human body has a mechanism for balancing the generation and neutralization of reactive oxygen species. The body is exposed to many agents that are responsible for the generation of reactive oxygen/nitrogen species, which leads… read more here.
Keywords: oxygen; reactive oxygen; oxygen species; membrane bound ... See more keywords
Characteristics of membrane-bound fatty acid desaturase (FAD) genes in Brassica napus L. and their expressions under different cadmium and salinity stresses
Sign Up to like & getrecommendations! Published in 2019 at "Environmental and Experimental Botany"
DOI: 10.1016/j.envexpbot.2019.02.016
Abstract: Abstract The membrane-bound fatty acid desaturases (FADs) play vital roles in regulating plant fatty acid (FA) compositions which directly affect oil quality in rapeseed (Brassica napus L.). In the present study, a total of 68… read more here.
Keywords: fad genes; fad; membrane bound; bound fatty ... See more keywords
Genome-wide investigation and expression analysis of membrane-bound fatty acid desaturase genes under different biotic and abiotic stresses in sunflower (Helianthus annuus L.).
Sign Up to like & getrecommendations! Published in 2021 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2021.02.013
Abstract: Membrane-bound fatty acid desaturases (FADs) gene family plays crucial roles in regulation of fatty acid (FA) compositions in plants. Sunflower (Helianthus annuus L.) is an important oilseed crop in the world; however, no comprehensive study… read more here.
Keywords: membrane bound; analysis; fatty acid; expression ... See more keywords
The N-Terminal Segment of the Voltage-Dependent Anion Channel: A Possible Membrane-Bound Intermediate in Pore Unbinding.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2018.09.015
Abstract: The voltage-dependent anion channel (VDAC) resides in the outer mitochondrial membrane and can adopt a closed or open configuration, most likely depending on whether the N-terminal segment (NTS) occupies the pore or protrudes into the… read more here.
Keywords: dependent anion; membrane bound; anion channel; voltage dependent ... See more keywords
Tau45-230 association with the cytoskeleton and membrane-bound organelles: Functional implications in neurodegeneration
Sign Up to like & getrecommendations! Published in 2017 at "Neuroscience"
DOI: 10.1016/j.neuroscience.2017.08.026
Abstract: The dysregulation of posttranslational modifications of the microtubule-associated protein (MAP) tau plays a key role in Alzheimer's disease (AD) and related disorders. Thus, we have previously shown that beta amyloid (Aβ)-induced neurotoxicity was mediated, at… read more here.
Keywords: tau45 230; cytoskeleton; tau; membrane bound ... See more keywords
Membrane-Bound Vimentin Filaments Reorganize and Elongate under Strain.
Sign Up to like & getrecommendations! Published in 2023 at "Biomacromolecules"
DOI: 10.1021/acs.biomac.3c00025
Abstract: Within a cell, intermediate filaments interact with other cytoskeletal components, altogether providing the cell's mechanical stability. However, little attention has been drawn to intermediate filaments close to the plasma membrane. In this cortex configuration, the… read more here.
Keywords: filaments reorganize; microscopy; vimentin filaments; bound vimentin ... See more keywords