A Critical Analysis of Molecular Mechanisms Underlying Membrane Cholesterol Sensitivity of GPCRs.
Sign Up to like & getrecommendations! Published in 2019 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-030-04278-3_2
Abstract: G protein-coupled receptors (GPCRs) are the largest and a diverse family of proteins involved in signal transduction across biological membranes. GPCRs mediate a wide range of physiological processes and have emerged as major targets for… read more here.
Keywords: cholesterol; sensitivity gpcrs; cholesterol sensitivity; membrane cholesterol ... See more keywords
O2 permeability of lipid bilayers is low, but increases with membrane cholesterol
Sign Up to like & getrecommendations! Published in 2021 at "Cellular and Molecular Life Sciences"
DOI: 10.1007/s00018-021-03974-9
Abstract: Oxygen on its transport route from lung to tissue mitochondria has to cross several cell membranes. The permeability value of membranes for O2 (PO2), although of fundamental importance, is controversial. Previous studies by mostly indirect… read more here.
Keywords: lipid bilayers; po2; cholesterol; membrane cholesterol ... See more keywords
Platelet tissue factor activity and membrane cholesterol are increased in hypercholesterolemia and normalized by rosuvastatin, but not by atorvastatin.
Sign Up to like & getrecommendations! Published in 2017 at "Atherosclerosis"
DOI: 10.1016/j.atherosclerosis.2016.12.019
Abstract: BACKGROUND AND AIMS High plasma LDL-cholesterol (LDL-C) and platelet responses have major pathogenic roles in atherothrombosis. Thus, statins and anti-platelet drugs constitute mainstays in cardiovascular prevention/treatment. However, the role of platelet tissue factor-dependent procoagulant activity… read more here.
Keywords: rosuvastatin; cholesterol; pca; membrane cholesterol ... See more keywords
Target Membrane Cholesterol Modulates Single Influenza Virus Membrane Fusion Efficiency but Not Rate.
Sign Up to like & getrecommendations! Published in 2020 at "Biophysical journal"
DOI: 10.1016/j.bpj.2020.03.021
Abstract: Host lipid composition influences many stages of the influenza A virus (IAV) entry process, including initial binding of IAV to sialylated glycans, fusion between the viral envelope and the host membrane, and the formation of… read more here.
Keywords: target membrane; membrane cholesterol; target; fusion ... See more keywords
Membrane cholesterol removal and replenishment affect rat and monkey brain monoamine transporters
Sign Up to like & getrecommendations! Published in 2018 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2018.01.039
Abstract: ABSTRACT The dopamine transporter (DAT) is abundantly expressed in the striatum where it removes extracellular dopamine into the cytosol of presynaptic nerve terminals. It is the target of drugs of abuse and antidepressants. There is… read more here.
Keywords: cholesterol; cholesterol removal; dat; membrane cholesterol ... See more keywords
Membrane cholesterol mediates the cellular effects of monolayer graphene substrates
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-03185-0
Abstract: Graphene possesses extraordinary properties that promise great potential in biomedicine. However, fully leveraging these properties requires close contact with the cell surface, raising the concern of unexpected biological consequences. Computational models have demonstrated that graphene… read more here.
Keywords: graphene; cholesterol; cellular effects; membrane cholesterol ... See more keywords
Membrane cholesterol and substrate stiffness co-ordinate to induce the remodelling of the cytoskeleton and the alteration in the biomechanics of vascular smooth muscle cells.
Sign Up to like & getrecommendations! Published in 2019 at "Cardiovascular research"
DOI: 10.1093/cvr/cvy276
Abstract: AIMS Cholesterol not only deposits in foam cells at the atherosclerotic plaque, but also plays an important role as a regulator of cell migration in atherogenesis. In addition, the progression of atherosclerosis leads to arterial… read more here.
Keywords: stiffness; biomechanics; vsmcs; cholesterol ... See more keywords
Cholesterol depletion following chronic hypoxia unmasks EGFR-signaling in pulmonary vascular smooth muscle through disinhibition of Rac1
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5731779
Abstract: Introduction: Chronic hypoxia (CH) leads to increased pulmonary vascular resistance and resultant pulmonary hypertension (PH) in patients with chronic obstructive pulmonary disease and sleep apnea. We recently demonstrated that CH augments vasoconstrictor reactivity through a… read more here.
Keywords: disinhibition; membrane cholesterol; rac1; physiology ... See more keywords
Depletion of membrane cholesterol compromised caspase-8 imparts in autophagy induction and inhibition of cell migration in cancer cells
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Cell International"
DOI: 10.1186/s12935-018-0520-4
Abstract: BackgroundCholesterol in lipid raft plays crucial role on cancer cell survival during metastasis of cancer cells. Cancer cells are reported to enrich cholesterol in lipid raft which make them more susceptible to cell death after… read more here.
Keywords: caspase; membrane cholesterol; cholesterol; cancer cells ... See more keywords
Membrane cholesterol regulates inhibition and substrate transport by the glycine transporter, GlyT2
Sign Up to like & getrecommendations! Published in 2022 at "Life Science Alliance"
DOI: 10.26508/lsa.202201708
Abstract: Cholesterol binds to the GlyT2 SLC6 transporter, enhancing the effect of bioactive lipid analgesics, providing new therapeutic avenues to treat neuropathic pain and target SLC6 transporters. Membrane cholesterol binds to and modulates the function of… read more here.
Keywords: inhibition; membrane cholesterol; transport; glyt2 ... See more keywords
Aging Increases Hippocampal DUSP2 by a Membrane Cholesterol Loss-Mediated RTK/p38MAPK Activation Mechanism
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Neurology"
DOI: 10.3389/fneur.2019.00675
Abstract: Numerous studies suggest that the increased activity of p38MAPK plays an important role in the abnormal immune and inflammatory response observed in the course of neurodegenerative diseases such as Alzheimer's disease. On the other hand,… read more here.
Keywords: membrane cholesterol; activity; p38mapk activity;