Cisplatin‐induced alteration on membrane composition of A549 cells revealed by ToF‐SIMS
Sign Up to like & getrecommendations! Published in 2019 at "Surface and Interface Analysis"
DOI: 10.1002/sia.6714
Abstract: Cisplatin has been clinically used for treatment of solid tumors such as non–small‐cell lung cancer for decades. However, tumor resistance may be acquired with losing the antitumor activity of cisplatin. As cellular membrane is the… read more here.
Keywords: a549 ddp; tof sims; membrane; membrane composition ... See more keywords
From Membrane Composition to Antimicrobial Strategies: Experimental and Computational Approaches to AMP Design and Selectivity.
Sign Up to like & getrecommendations! Published in 2025 at "Small"
DOI: 10.1002/smll.202411476
Abstract: The United Nations have committed to end the epidemics of communicable diseases by 2030 (SDG Target 3.3). In contrast with this ambition, the rise of Multi Drug Resistant (MDR) and Pan Drug Resistant (PDR) bacteria… read more here.
Keywords: membrane composition; antimicrobial strategies; drug; selectivity ... See more keywords
All-Atom Simulations Reveal the Effect of Membrane Composition on the Signaling of the NKG2A/CD94/HLA-E Immune Receptor Complex
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Chemical Information and Modeling"
DOI: 10.1021/acs.jcim.4c01357
Abstract: Understanding how membrane composition influences the dynamics and function of transmembrane proteins is crucial for the comprehensive elucidation of cellular signaling mechanisms and the development of targeted therapeutics. In this study, we employed all-atom molecular… read more here.
Keywords: nkg2a cd94; membrane composition; cd94 hla; membrane ... See more keywords
KIF13B establishes a CAV1-enriched microdomain at the ciliary transition zone to promote Sonic hedgehog signalling
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/ncomms14177
Abstract: Ciliary membrane composition is controlled by transition zone (TZ) proteins such as RPGRIP1, RPGRIPL and NPHP4, which are vital for balanced coordination of diverse signalling systems like the Sonic hedgehog (Shh) pathway. Activation of this… read more here.
Keywords: sonic hedgehog; membrane composition; transition zone;
Precise control of transmembrane current via regulating bionic lipid membrane composition
Sign Up to like & getrecommendations! Published in 2024 at "Science Advances"
DOI: 10.1126/sciadv.adq0118
Abstract: The transport of ions through biological ion channels is regulated not only by their structural characteristics but also by the composition of the phospholipid membrane, which serves as a carrier for nanochannels. Inspired by the… read more here.
Keywords: composition; membrane composition; precise control; ion ... See more keywords
Doxorubicin Inhibits Phosphatidylserine Decarboxylase and Modifies Mitochondrial Membrane Composition in HeLa Cells
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms21041317
Abstract: Doxorubicin (DXR) is a drug widely used in chemotherapy. Its mode of action is based on its intercalation properties, involving the inhibition of topoisomerase II. However, few studies have reported the mitochondrial effects of DXR… read more here.
Keywords: phosphatidylserine decarboxylase; mitochondrial membrane; membrane; membrane composition ... See more keywords