Illuminating the membrane contact sites between the endoplasmic reticulum and the trans‐Golgi network
Sign Up to like & getrecommendations! Published in 2019 at "FEBS Letters"
DOI: 10.1002/1873-3468.13639
Abstract: Membrane contact sites (MCSs) between different organelles have been identified and extensively studied over the last decade. Several classes of MCSs have now well‐established roles, although the contacts between the endoplasmic reticulum (ER) and the… read more here.
Keywords: membrane contact; endoplasmic reticulum; golgi network; contact sites ... See more keywords
Vacuole membrane contact sites regulate liquid-ordered domain formation during glucose starvation.
Sign Up to like & getrecommendations! Published in 2023 at "FEBS letters"
DOI: 10.1002/1873-3468.14621
Abstract: Liquid-ordered (Lo) membrane domains have been proposed to play important roles in a wide variety of biological processes, such as protein sorting and cell signaling. However, the mechanisms by which they are formed and maintained… read more here.
Keywords: glucose starvation; contact sites; membrane contact; domain formation ... See more keywords
Glycosphingolipids within membrane contact sites influence their function as signaling hubs in neurodegenerative diseases.
Sign Up to like & getrecommendations! Published in 2023 at "FEBS open bio"
DOI: 10.1002/2211-5463.13605
Abstract: Intracellular organelles carry out many of their functions by engaging in extensive inter-organellar communication through specialized membrane contact sites (MCSs) formed where two organelles tether to each other or to the plasma membrane without fusing.… read more here.
Keywords: contact sites; membrane contact; signaling hubs; membrane ... See more keywords
The Role of Mitochondria in the Activation/Maintenance of SOCE: Membrane Contact Sites as Signaling Hubs Sustaining Store-Operated Ca2+ Entry.
Sign Up to like & getrecommendations! Published in 2017 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-319-57732-6_15
Abstract: Store-operated Ca2+ entry (SOCE) is a cell signaling pathway essential for immune and muscle function controlled by dynamic interactions between Ca2+-sensing STIM proteins on the endoplasmic reticulum (ER) and Ca2+-permeable ORAI channels on the plasma… read more here.
Keywords: store operated; contact sites; membrane contact; operated ca2 ... See more keywords
Super-Resolution Imaging of Organelle Membrane Contact Sites via Far-Red Hyperspectral Localization Microscopy
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2016.11.780
Abstract: The communication and exchange of material between subcellular organelles is critical to many cellular processes. Areas of close apposition between organelles, termed membrane contact sites (MCS), have recently become a focus of study for intracellular… read more here.
Keywords: membrane contact; microscopy; hyperspectral localization; contact sites ... See more keywords
An Endosomal NAADP-Sensitive Two-Pore Ca2+ Channel Regulates ER-Endosome Membrane Contact Sites to Control Growth Factor Signaling
Sign Up to like & getrecommendations! Published in 2017 at "Cell Reports"
DOI: 10.1016/j.celrep.2017.01.052
Abstract: Summary Membrane contact sites are regions of close apposition between organelles that facilitate information transfer. Here, we reveal an essential role for Ca2+ derived from the endo-lysosomal system in maintaining contact between endosomes and the… read more here.
Keywords: membrane contact; contact sites; ca2; contact ... See more keywords
An Intrinsically Disordered Region in OSBP Acts as an Entropic Barrier to Control Protein Dynamics and Orientation at Membrane Contact Sites.
Sign Up to like & getrecommendations! Published in 2019 at "Developmental cell"
DOI: 10.1016/j.devcel.2019.02.021
Abstract: Lipid transfer proteins (LTPs) acting at membrane contact sites (MCS) between the ER and other organelles contain domains involved in heterotypic (e.g., ER to Golgi) membrane tethering as well as domains involved in lipid transfer.… read more here.
Keywords: protein; membrane contact; contact sites; entropic barrier ... See more keywords
VAP-A and its binding partner CERT drive biogenesis of RNA-containing extracellular vesicles at ER membrane contact sites.
Sign Up to like & getrecommendations! Published in 2022 at "Developmental cell"
DOI: 10.1016/j.devcel.2022.03.012
Abstract: RNA transfer via extracellular vesicles (EVs) influences cell phenotypes; however, lack of information regarding biogenesis of RNA-containing EVs has limited progress in the field. Here, we identify endoplasmic reticulum membrane contact sites (ER MCSs) as… read more here.
Keywords: biogenesis rna; membrane contact; extracellular vesicles; rna containing ... See more keywords
Plant Endoplasmic Reticulum-Plasma Membrane Contact Sites.
Sign Up to like & getrecommendations! Published in 2017 at "Trends in plant science"
DOI: 10.1016/j.tplants.2016.11.008
Abstract: The endoplasmic reticulum (ER) acts as a superhighway with multiple sideroads that connects the different membrane compartments including the ER to the plasma membrane (PM). ER-PM contact sites (EPCSs) are a common feature in eukaryotic… read more here.
Keywords: membrane contact; endoplasmic reticulum; plant; contact sites ... See more keywords
A new type of ERGIC–ERES membrane contact mediated by TMED9 and SEC12 is required for autophagosome biogenesis
Sign Up to like & getrecommendations! Published in 2021 at "Cell Research"
DOI: 10.1038/s41422-021-00563-0
Abstract: Under stress, the endomembrane system undergoes reorganization to support autophagosome biogenesis, which is a central step in autophagy. How the endomembrane system remodels has been poorly understood. Here we identify a new type of membrane… read more here.
Keywords: ergic eres; sec12; autophagosome biogenesis; membrane contact ... See more keywords
Stepping outside the comfort zone of membrane contact site research
Sign Up to like & getrecommendations! Published in 2018 at "Nature Reviews Molecular Cell Biology"
DOI: 10.1038/s41580-018-0022-1
Abstract: The past decade has seen striking progress in our understanding of communication between organelles via close appositions of their membranes, known as contact sites. Recent systematic studies highlight that the cellular contact site landscape is… read more here.
Keywords: membrane contact; contact sites; contact site; comfort zone ... See more keywords