Live Cell Strategy for Detection of Curvature Dependent Sorting of Membrane Associated Proteins
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2016.11.1606
Abstract: The curvature of cellular membranes varies a lot from organelle to organelle and within small subsections of the plasma membrane. A growing amount of evidence suggests that membrane curvature serves a purpose of regulating oligomerization,… read more here.
Keywords: cell strategy; live cell; membrane curvature; membrane ... See more keywords
Interplay between Membrane Curvature and Cholesterol: Role of Palmitoylated Caveolin-1.
Sign Up to like & getrecommendations! Published in 2019 at "Biophysical journal"
DOI: 10.1016/j.bpj.2018.11.3127
Abstract: Caveolin-1 (cav-1) is an important player in cell signaling and endocytosis that has been shown to colocalize with cholesterol-rich membrane domains. Experimental studies with varying cav-1 constructs have suggested that it can induce both cholesterol… read more here.
Keywords: curvature cholesterol; membrane curvature; cholesterol; membrane ... See more keywords
Membrane curvature affects the stability and folding kinetics of bacteriorhodopsin
Sign Up to like & getrecommendations! Published in 2019 at "Process Biochemistry"
DOI: 10.1016/j.procbio.2018.10.002
Abstract: Abstract Biological membrane is crucial for the function, stability and folding of membrane proteins. By studying the stability and folding kinetics of bacteriorhodopsin (bR) in lipid vesicles with different sizes, here we report the influence… read more here.
Keywords: stability folding; membrane curvature; folding kinetics; stability ... See more keywords
Polymyxin Binding to the Bacterial Outer Membrane Reveals Cation Displacement and Increasing Membrane Curvature in Susceptible but Not in Resistant Lipopolysaccharide Chemotypes.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of chemical information and modeling"
DOI: 10.1021/acs.jcim.7b00271
Abstract: Lipid-A is the causative agent of Gram-negative sepsis and is responsible for an increasingly high mortality rate among hospitalized patients. Compounds that bind Lipid-A can limit this inflammatory process. The cationic antimicrobial peptide polymyxin B… read more here.
Keywords: binding bacterial; bacterial outer; outer membrane; membrane curvature ... See more keywords
Mechanisms of Uptake and Membrane Curvature Generation for the Internalization of Silica Nanoparticles by Cells
Sign Up to like & getrecommendations! Published in 2022 at "Nano Letters"
DOI: 10.1021/acs.nanolett.2c00537
Abstract: Nanosized drug carriers enter cells via active mechanisms of endocytosis but the pathways involved are often not clarified. Cells possess several mechanisms to generate membrane curvature during uptake. However, the mechanisms of membrane curvature generation… read more here.
Keywords: silica nanoparticles; curvature generation; generation internalization; membrane curvature ... See more keywords
Dynamic Manipulation of Cell Membrane Curvature by Light-Driven Reshaping of Azopolymer.
Sign Up to like & getrecommendations! Published in 2019 at "Nano letters"
DOI: 10.1021/acs.nanolett.9b04307
Abstract: Local curvatures on the cell membrane serve as signaling hubs that promote curvature-dependent protein interactions and modulate a variety of cellular processes including endocytosis, exocytosis, and the actin cytoskeleton. However, precisely controlling the location and… read more here.
Keywords: dynamic manipulation; cell membrane; membrane curvatures; membrane curvature ... See more keywords
A Membrane Curvature Modulated Lipopeptide to Broadly Combat Multidrug-Resistant Bacterial Pneumonia with Low Resistance Risk.
Sign Up to like & getrecommendations! Published in 2022 at "ACS nano"
DOI: 10.1021/acsnano.2c07251
Abstract: The extensive spread of multidrug resistance to Gram-negative bacteria has become a huge threat to human health, where peptide-based antibacterial agents have emerged as a powerful star weapon. Here we report a lipopeptide (LP-20) constructed… read more here.
Keywords: multidrug; membrane curvature; resistance; multidrug resistant ... See more keywords
Self-Assembly and Disassembly of Membrane Curvature-Sensing Peptide-Based Deep-Red Fluorescent Probe for Highly Sensitive Sensing of Exosomes.
Sign Up to like & getrecommendations! Published in 2023 at "ACS sensors"
DOI: 10.1021/acssensors.2c02498
Abstract: With increasing knowledge of the diverse roles of exosomes in biological processes, much attention has been paid to the development of analytical methods for exosome analysis. Here, we developed a new class of amphipathic helical… read more here.
Keywords: peptide based; self assembly; membrane curvature; sensing peptide ... See more keywords
A nanostructure platform for live-cell manipulation of membrane curvature
Sign Up to like & getrecommendations! Published in 2019 at "Nature Protocols"
DOI: 10.1038/s41596-019-0161-7
Abstract: Membrane curvatures are involved in essential cellular processes, such as endocytosis and exocytosis, in which they are believed to act as microdomains for protein interactions and intracellular signaling. These membrane curvatures appear and disappear dynamically,… read more here.
Keywords: live cell; membrane curvatures; membrane curvature; membrane ... See more keywords
Membrane curvature induces cardiolipin sorting
Sign Up to like & getrecommendations! Published in 2019 at "Communications Biology"
DOI: 10.1038/s42003-019-0471-x
Abstract: Cardiolipin is a cone-shaped lipid predominantly localized in curved membrane sites of bacteria and in the mitochondrial cristae. This specific localization has been argued to be geometry-driven, since the CL’s conical shape relaxes curvature frustration.… read more here.
Keywords: cardiolipin sorting; induces cardiolipin; membrane curvature; curvature induces ... See more keywords
Interplay of septin amphipathic helices in sensing membrane-curvature and filament bundling
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Biology of the Cell"
DOI: 10.1091/mbc.e20-05-0303
Abstract: The curvature of the membrane defines cell shape. Septins are GTP-binding proteins that assemble into heteromeric complexes and polymerize into filaments at areas of micron-scale membrane curvature. An amphipathic helix (AH) domain within the septin… read more here.
Keywords: membrane curvature; curvature; septin; domain ... See more keywords