Membrane-Anchoring, Comb-Like Pseudopeptides for Efficient, pH-Mediated Membrane Destabilization and Intracellular Delivery.
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DOI: 10.1021/acsami.7b00498
Abstract: Endosomal release has been identified as a rate-limiting step for intracellular delivery of therapeutic agents, in particular macromolecular drugs. Herein, we report a series of synthetic pH-responsive, membrane-anchoring polymers exhibiting dramatic endosomolytic activity for efficient… read more here.
Keywords: delivery; intracellular delivery; membrane destabilization; membrane anchoring ... See more keywords
Cytotoxicity and bacterial membrane destabilization induced by Annona squamosa L. extracts.
Sign Up to like & getrecommendations! Published in 2017 at "Anais da Academia Brasileira de Ciencias"
DOI: 10.1590/0001-3765201720150702
Abstract: This study aimed to further investigate the cytotoxicity against tumor cell lines and several bacterial strains of Annona squamosa and its mode of action. Methanol extracts of A. squamosa leaves (ASL) and seeds (ASS) were… read more here.
Keywords: membrane destabilization; annona squamosa; cytotoxicity bacterial; bacterial membrane ... See more keywords